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Optimization of a perfusion bioreactor for tissue engineering

2014-06-11Capítulo de livro Acesso restrito
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Médica
datacite.subject.fosEngenharia e Tecnologia::Outras Engenharias e Tecnologias
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorFreitas, D.
dc.contributor.authorAlmeida, H.A.
dc.contributor.authorBártolo, P.
dc.date.accessioned2026-07-15T13:00:01Z
dc.date.available2026-07-15T13:00:01Z
dc.date.issued2014-06-11
dc.description.abstractTissue engineering aims to produce artificial tissue in order to create or repair the damage tissue. It is evident that scaffolds are of extreme importance, because they will be the support of the new tissue. This new tissue is cultivated in vitro in a bioreactor in which is placed the scaffold. In order to control the cell culture process inside of a bioreactor it is essential to know the fluid flow inside and around the scaffold and the respective wall shear stress. These wall shear stress must be adequate to the tissue to be cultivated, i.e., bone, muscle, cartilage and it is known that a proper stimulus is necessary to improve the cell proliferation inside the scaffold. This study consider a novel multifunctional bioreactor with a perfusion system module and it is intended to optimize the fluid flow within the scaffold and the respective wall shear stress on the scaffold.eng
dc.description.sponsorshipThe authors acknowledge the support of the Strategic Project (PEST-OE/EME/UI4044/2013) funded by the Portuguese Foundation for Science and Technology. Authors also acknowledge the support of the European Commission through the Marie Curie Project “International Research Exchange for Biomedical Devices Design and Prototyping” “IREBID”.
dc.identifier.citationFreitas, D., Almeida, H. A., & Bártolo, P. (2014). Optimization of a perfusion bioreactor for tissue engineering. In R. M. Natal Jorge, J. M. R. S. Tavares, J. C. R. Reis Campos, N. V. Ramos, & M. A. Vaz (Eds.), Biodental Engineering III (pp. 145–150). CRC Press. https://doi.org/10.1201/b17071-31
dc.identifier.doi10.1201/b17071-31
dc.identifier.isbn978-1-138-02671-1
dc.identifier.urihttp://hdl.handle.net/10400.8/16597
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis Group
dc.relationStrategic Project - UI 4044 - 2013-2014
dc.relation.hasversionhttps://www.taylorfrancis.com/chapters/edit/10.1201/b17071-31/optimization-perfusion-bioreactor-tissue-engineering-freitas-almeida-b%C3%A1rtolo?context=ubx&refId=4db42544-b5a0-436f-a3d6-a42a089e7965
dc.relation.ispartofBiodental Engineering III
dc.relation.ispartofseriesBiodental Engineering
dc.rights.uriN/A
dc.subjectTissue engineering
dc.subjectscaffolds
dc.subjectbioreactor
dc.subjectperfusion system
dc.subjectfluid flow
dc.subjectwall shear stress
dc.titleOptimization of a perfusion bioreactor for tissue engineeringeng
dc.typebook part
dspace.entity.typePublication
oaire.awardNumberPEst-OE/EME/UI4044/2013
oaire.awardTitleStrategic Project - UI 4044 - 2013-2014
oaire.awardURIhttp://hdl.handle.net/10400.8/13452
oaire.citation.endPage150
oaire.citation.startPage145
oaire.citation.titleBiodental Engineering III - Proceedings of the 3rd International Conference on Biodental Engineering, BIODENTAL 2014
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFreitas
person.familyNameAlmeida
person.familyNameBartolo
person.givenNameDino
person.givenNameHenrique de Amorim
person.givenNamePaulo
person.identifier133710
person.identifier46395
person.identifier203086
person.identifier.ciencia-id1A1F-4FE8-9D40
person.identifier.ciencia-id8F1D-4370-84BE
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0003-1094-8527
person.identifier.orcid0000-0002-1367-2290
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridN-7893-2015
person.identifier.ridD-6275-2012
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55795311300
person.identifier.scopus-author-id55938867800
person.identifier.scopus-author-id6603353041
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relation.isAuthorOfPublicationf3bfdd6a-e959-4e13-8a20-fb1b286a3dd0
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