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Early immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infection

2022Journal article Open access
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dc.contributor.authorVaz, Mariana
dc.contributor.authorPires, Damiana
dc.contributor.authorPires, Pedro
dc.contributor.authorSimões, Marco
dc.contributor.authorPombo, Ana
dc.contributor.authorSantos, Paulo
dc.contributor.authorCarmo, Beatriz do
dc.contributor.authorPassos, Ricardo
dc.contributor.authorCosta, Janina Z.
dc.contributor.authorThompson, Kim D.
dc.contributor.authorBaptista, Teresa
dc.date.accessioned2022-04-04T14:54:59Z
dc.date.available2022-04-04T14:54:59Z
dc.date.issued2022
dc.date.updated2022-03-25T18:29:00Z
dc.descriptionFunding: This study was supported by Fundação para a Ciência e Tecnologia (FCT) through the strategic projects UIDB /04292/2020 and UIDP/04292/2020 granted to MARE and the project MAR02.05.01-FEAMP-0013.pt_PT
dc.description.abstractThe early host–pathogen interaction between European seabass (Dicentrarchus labrax) and Betanodavirus was examined by using juvenile fish infected intramuscularly with RGNNV (red-spotted grouper nervous necrosis virus). The time course selected for sampling (0–144 h post-infection (hpi)) covered the early stages of infection, with hematological, antioxidant and immunological responses examined. Early activation of the host’s immune system was seen in the first few hours post-infection (6 to 9 hpi), as evidenced by an increase in tnfa, cd28 and c3 expression in the head kidney of infected fish. Most hematological parameters that were examined showed significant differences between sampling times, including differences in the number of thrombocytes and various leukocyte populations. The plasma lysozyme concentration decreased significantly over the course of the trial, and most antioxidant parameters examined in the liver showed significant differences over the infection period. At 144 hpi, peak expression of tnfa and il-1b coincided with the appearance of disease symptoms, peak levels of virus in the brain and high levels of fish mortality. The results of the study show the importance of analyzing the early interactions between European seabass and Betanodavirus to establish early indicators of infection to prevent more severe outcomes of the infection from occurring.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVaz, M.; Pires, D.; Pires, P.; Simões, M.; Pombo, A.; Santos, P.; do Carmo, B.; Passos, R.; Costa, J.Z.; Thompson, K.D.; et al. Early Immune Modulation in European Seabass (Dicentrarchus labrax) Juveniles in Response to Betanodavirus Infection. Fishes 2022, 7, 63. https://doi.org/ 10.3390/fishes7020063pt_PT
dc.identifier.doi10.3390/fishes7020063pt_PT
dc.identifier.issn2410-3888
dc.identifier.slugcv-prod-2962456
dc.identifier.urihttp://hdl.handle.net/10400.8/6911
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherMDPIpt_PT
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEuropean seabasspt_PT
dc.subjectNervous necrosis viruspt_PT
dc.subjectBetanodaviruspt_PT
dc.subjectHematologypt_PT
dc.subjectOxidative stresspt_PT
dc.subjectFish immunitypt_PT
dc.titleEarly immune modulation in European Seabass (Dicentrarchus labra) juveniles in response to Betanodavirus infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04292%2F2020/PT
oaire.citation.titleFishespt_PT
oaire.citation.volume7pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameVaz
person.familyNamePires
person.familyNamePires
person.familyNameDias Simões
person.familyNamePombo
person.familyNameCarmo
person.familyNamePassos
person.familyNameBaptista
person.givenNameMariana
person.givenNameDamiana
person.givenNamePedro
person.givenNameMarco Aurélio
person.givenNameAna
person.givenNameBeatriz
person.givenNameRicardo
person.givenNameTeresa
person.identifier712192
person.identifier.ciencia-idEC11-F452-DC1C
person.identifier.ciencia-id911B-3AE7-BA43
person.identifier.ciencia-id1D1C-C217-F68A
person.identifier.ciencia-id0F1C-22B0-7990
person.identifier.ciencia-idA61F-25C1-034A
person.identifier.orcid0000-0001-6064-0227
person.identifier.orcid0000-0002-6763-6498
person.identifier.orcid0000-0002-0748-0890
person.identifier.orcid0000-0001-7995-7304
person.identifier.orcid0000-0003-1397-9206
person.identifier.orcid0000-0002-0572-3748
person.identifier.orcid0000-0003-4632-4492
person.identifier.orcid0000-0003-1168-7461
person.identifier.scopus-author-id56763918700
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaidA61F-25C1-034A | Teresa Maria Coelho Baptista
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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