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Synthetic Membranes as an Alternative to Animal Skin to Investigate Dermal Permeation of Chlorpyrifos

2022-07-04Comunicação em conferência Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg11:Cidades e Comunidades Sustentáveis
dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2026-03-16T12:28:56Z
dc.date.available2026-03-16T12:28:56Z
dc.date.issued2022-07-04
dc.descriptionArticle number - 3
dc.descriptionThis article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology — Current Challenges.
dc.descriptionProceeding Paper - Presented at the Biosystems in Toxicology and Pharmacology—Current challenges, Online, 8–9 September 2022; Available online: https://bitap.sciforum.net/
dc.description.abstractChlorpyrifos is a pesticide revised as dangerous for human health. While dermal permeation of chlorpyrifos is still poorly investigated, alternatives to animal and/or human skin are demanded. In this work, the suitability of synthetic membranes as alternative models to study dermal permeation of chlorpyrifos was investigated. Silicone and STRAT-M® membranes were tested on Franz cells using different receptor compositions. By adapting the concentration of ethanol in the receptor fluid, the results of chlorpyrifos permeation through both membranes were close to those found in human skin studies, supporting the use of those membranes as non-animal skin-equivalent models.eng
dc.description.sponsorshipFunding: This research was funded by FUNDAÇÃO PARA A CIÊNCIA e TECNOLOGIA (FCT—Portugal), grant number PTDC/BIA-MIB/31864/2017 and by LA/P/0045/2020 (ALiCE), UIDB/50020/2020 and UIDP/50020/2020 (LSRE-LCM), funded by national funds through FCT/MCTES (PIDDAC).
dc.identifier.citationMarques-da-Silva, D., & Lagoa, R. (2022). Synthetic Membranes as an Alternative to Animal Skin to Investigate Dermal Permeation of Chlorpyrifos. Medical Sciences Forum, 11(1), 3. https://doi.org/10.3390/BiTaP-12786
dc.identifier.doi10.3390/bitap-12786
dc.identifier.eissn2673-9992
dc.identifier.urihttp://hdl.handle.net/10400.8/15877
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relation.hasversionhttps://www.mdpi.com/2673-9992/11/1/3
dc.relation.ispartofBiosystems in Toxicology and Pharmacology—Current Challenges
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectorganophosphorus pesticide
dc.subjectskin permeation
dc.subjectpolymeric membranes
dc.subjectalternative methods
dc.subjectenvironmental and occupational toxicology
dc.titleSynthetic Membranes as an Alternative to Animal Skin to Investigate Dermal Permeation of Chlorpyrifoseng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberPTDC/BIA-MIB/31864/2017
oaire.awardNumberLA/P/0045/2020
oaire.awardNumberUIDB/50020/2020
oaire.awardNumberUIDP/50020/2020
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0045%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50020%2F2020/PT
oaire.citation.conferenceDate2022-09
oaire.citation.endPage4
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleMedical Sciences Forum
oaire.citation.volume11
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMarques da Silva
person.familyNameLagoa
person.givenNameDorinda
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0003-0460-5421
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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By Dorinda Marques-da-Silva and Ricardo Lagoa Med. Sci. Forum 2022, 11(1), 3; https://doi.org/10.3390/BiTaP-12786 Published: 4 July 2022 (This article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology—Current Challenges)
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