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Synthetic Membranes as an Alternative to Animal Skin to Investigate Dermal Permeation of Chlorpyrifos
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| By Dorinda Marques-da-Silva and Ricardo Lagoa Med. Sci. Forum 2022, 11(1), 3; https://doi.org/10.3390/BiTaP-12786 Published: 4 July 2022 (This article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology—Current Challenges) | 635.96 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Chlorpyrifos is a pesticide revised as dangerous for human health. While dermal permeation of chlorpyrifos is still poorly investigated, alternatives to animal and/or human skin are demanded. In this work, the suitability of synthetic membranes as alternative models to study dermal permeation of chlorpyrifos was investigated. Silicone and STRAT-M® membranes were tested on Franz cells using different receptor compositions. By adapting the concentration of ethanol in the receptor fluid, the results of chlorpyrifos permeation through both membranes were close to those found in human skin studies, supporting the use of those membranes as non-animal skin-equivalent models.
Descrição
Article number - 3
This article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology — Current Challenges.
Proceeding Paper - Presented at the Biosystems in Toxicology and Pharmacology—Current challenges, Online, 8–9 September 2022; Available online: https://bitap.sciforum.net/
This article belongs to the Proceedings of Biosystems in Toxicology and Pharmacology — Current Challenges.
Proceeding Paper - Presented at the Biosystems in Toxicology and Pharmacology—Current challenges, Online, 8–9 September 2022; Available online: https://bitap.sciforum.net/
Palavras-chave
organophosphorus pesticide skin permeation polymeric membranes alternative methods environmental and occupational toxicology
Contexto Educativo
Citação
Marques-da-Silva, D., & Lagoa, R. (2022). Synthetic Membranes as an Alternative to Animal Skin to Investigate Dermal Permeation of Chlorpyrifos. Medical Sciences Forum, 11(1), 3. https://doi.org/10.3390/BiTaP-12786
Editora
MDPI