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Polycaprolactone-based scaffold plus BMP-2 in a sheep thoracic spine fusion model
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We report the application of a novel scaffold design in a sheep thoracic spine model for spine deformity correction. The combination of the calcium-phosphate coated polycaprolactone scaffolds with recombinant human bone morphogenic protein-2 are intended as a future bone graft substitute in ensuring the stability of bony intervertebral fusion. A solid free-form fabrication process based on melt extrusion has been utilized in the manufacturing of these scaffolds.
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Yong, M., Melchels, F., Vaquette, C., Hutmacher, D., & Adam, C. (2011, September). Polycaprolactone-based scaffold plus BMP-2 in a sheep thoracic spine. In Innovative Developments in Virtual and Physical Prototyping: Proceedings of the 5th International Conference on Advanced Research in Virtual and Rapid Prototyping, Leiria, Portugal, 28 September-1 October, 2011 (p. 89). CRC Press.