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Effect biomarkers of the widespread antimicrobial triclosan in a marine model diatom

2022Journal article Open access
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dc.contributor.authorDuarte, Bernardo
dc.contributor.authorFeijão, Eduardo
dc.contributor.authorCarvalho, Ricardo Cruz de
dc.contributor.authorMatos, Ana Rita
dc.contributor.authorCabrita, Maria Teresa
dc.contributor.authorNovais, Sara C.
dc.contributor.authorMoutinho, Ariana
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorMarques, João Carlos
dc.contributor.authorCaçador, Isabel
dc.contributor.authorReis-Santos, Patrick
dc.contributor.authorFonseca, Vanessa
dc.date.accessioned2023-08-24T11:17:06Z
dc.date.available2023-08-24T11:17:06Z
dc.date.issued2022
dc.descriptionThe authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research at MARE (UIDB/04292/2020 and UIDP/04292/2020), ARNET—Aquatic Research Infrastructure Network Associated Laboratory (LA/P/0069/2020), BioISI (UID/MULTI/04046/2019) and via project grant PTDC/CTA-AMB/30056/2017 (OPTOX).Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. B. Duarte and V. F. Fonseca were supported by researcher contracts (CEECIND/00511/2017 and 2021.00244.CEECIND). M.T. Cabrita is supported by a DL-57 investigation contract.pt_PT
dc.description.abstractThe present-day COVID-19 pandemic has led to the increasing daily use of antimicrobials worldwide. Triclosan is a manmade disinfectant chemical used in several consumer healthcare products, and thus frequently detected in surface waters. In the present work, we aimed to evaluate the effect of triclosan on diatom cell photophysiology, fatty acid profiles, and oxidative stress biomarkers, using the diatom Phaeodactylum tricornutum as a model organism. Several photochemical effects were observed, such as the lower ability of the photosystems to efficiently trap light energy. A severe depletion of fucoxanthin under triclosan application was also evident, pointing to potential use of carotenoid as reactive oxygen species scavengers. It was also observed an evident favouring of the peroxidase activity to detriment of the SOD activity, indicating that superoxide anion is not efficiently metabolized. High triclosan exposure induced high cellular energy allocation, directly linked with an increase in the energy assigned to vital functions, enabling cells to maintain the growth rates upon triclosan exposure. Oxidative stress traits were found to be the most efficient biomarkers as promising tools for triclosan ecotoxicological assessments. Overall, the increasing use of triclosan will lead to significant effects on the diatom photochemical and oxidative stress levels, compromising key roles of diatoms in the marine system.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDuarte, B.; Feijão, E.; Cruz de Carvalho, R.; Matos, A.R.; Cabrita, M.T.; Novais, S.C.; Moutinho, A.; Lemos, M.F.L.; Marques, J.C.; Caçador, I.; et al. Effect Biomarkers of theWidespread Antimicrobial Triclosan in a Marine Model Diatom. Antioxidants 2022, 11, 1442. https://doi.org/10.3390/ antiox11081442pt_PT
dc.identifier.doi10.3390/ antiox11081442pt_PT
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/10400.8/8728
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relationBiosystems & Integrative Sciences Institute
dc.relationDevelopment and validation of bio-optical ecotoxicological tests in marine phototrophs.
dc.relationNot Available
dc.relationSeaCODE - Seafood provenance and traceability tool development towards sustainable fisheries with science-based solutions
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/11/8/1442pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntimicrobialspt_PT
dc.subjectEcotoxicologypt_PT
dc.subjectEnergy metabolismpt_PT
dc.subjectPhotobiologypt_PT
dc.subjectPrimary producerspt_PT
dc.titleEffect biomarkers of the widespread antimicrobial triclosan in a marine model diatompt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleBiosystems & Integrative Sciences Institute
oaire.awardTitleDevelopment and validation of bio-optical ecotoxicological tests in marine phototrophs.
oaire.awardTitleNot Available
oaire.awardTitleSeaCODE - Seafood provenance and traceability tool development towards sustainable fisheries with science-based solutions
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04292%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00511%2F2017%2FCP1387%2FCT0039/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00244.CEECIND%2FCP1650%2FCT0010/PT
oaire.citation.issue8pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStream3599-PPCDT
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oaire.fundingStreamCEEC IND4ed
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