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Prevalence of quinolone resistance determinants in non-typhoidal Salmonella isolates from human origin in Extremadura, Spain

2014-05Artigo científico Acesso restrito
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datacite.subject.fosCiências Médicas::Outras Ciências Médicas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorCampos, Maria Jorge
dc.contributor.authorPalomo, Gonzalo
dc.contributor.authorHormeño, Lorena
dc.contributor.authorHerrera-León, Silvia
dc.contributor.authorDomínguez, Lucas
dc.contributor.authorVadillo, Santiago
dc.contributor.authorPíriz, Segundo
dc.contributor.authorQuesada, Alberto
dc.date.accessioned2026-06-30T17:14:13Z
dc.date.available2026-06-30T17:14:13Z
dc.date.issued2014-05
dc.description.abstractResistance to the quinolones nalidixic acid (NAL) and ciprofloxacin (CIP) and the occurrence of quinolone resistance determinants have been investigated in 300 non-typhoidal Salmonella from human origin, isolated in the years between 2004 and 2008, in 6 hospitals within Extremadura (Spain). Salmonella Enteritidis was the major serotype found among quinolone-resistant isolates, most of which were clustered by clonal analysis to a single clone, which presented D87 or S83 substitutions in GyrA. Eleven isolates presented the non-classical quinolone resistance phenotype (resistance to CIP and susceptibility to NAL), lacking mutations in the quinolone resistance determinant region of topoisomerase genes. Among them, one Salmonella Typhimurium isolate carried a qnrS1 gene in a low-molecular-weight plasmid, pQnrS1-HLR25, identical to plasmids previously found in the UK, Taiwan, and USA. The occurrence of this genetic element could represent a risk for the horizontal transmission of quinolone resistance among Enterobacteriaceae in the Iberian Peninsula.eng
dc.description.sponsorshipGP wishes to thank the Valhondo Calaff foundation for a predoctoral fellowship. This work has been supported by projects AGL2008-04147/GAN and AGL2012-39028-C03-03 (Ministry of Education and Science, Spain) and PRI08B001 (Department of Economy, Commerce and Innovation of the Regional Government of Extremadura, Spain).
dc.identifier.citationMaria Jorge Campos, Gonzalo Palomo, Lorena Hormeño, Silvia Herrera-León, Lucas Domínguez, Santiago Vadillo, Segundo Píriz, Alberto Quesada, Prevalence of quinolone resistance determinants in non-typhoidal Salmonella isolates from human origin in Extremadura, Spain, Diagnostic Microbiology and Infectious Disease, Volume 79, Issue 1, 2014, Pages 64-69, ISSN 0732-8893, https://doi.org/10.1016/j.diagmicrobio.2014.01.010.
dc.identifier.doi10.1016/j.diagmicrobio.2014.01.010
dc.identifier.eissn1879-0070
dc.identifier.issn0732-8893
dc.identifier.urihttp://hdl.handle.net/10400.8/16510
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0732889314000212?via%3Dihub
dc.relation.ispartofDiagnostic Microbiology and Infectious Disease
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAntimicrobial resistance
dc.subjectCiprofloxacin
dc.subjectMobilisable plasmid
dc.subjectNalidixic acid
dc.subjectPMQR
dc.subjectQuinolone resistance
dc.subjectSalmonella enterica
dc.subjectgyrA
dc.subjectgyrB
dc.subjectparC
dc.subjectparE
dc.subjectqnrS
dc.titlePrevalence of quinolone resistance determinants in non-typhoidal Salmonella isolates from human origin in Extremadura, Spaineng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage69
oaire.citation.issue1
oaire.citation.startPage64
oaire.citation.titleDiagnostic Microbiology and Infectious Disease
oaire.citation.volume79
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCampos
person.givenNameMaria Jorge
person.identifier174191
person.identifier.ciencia-id2416-7867-2D40
person.identifier.orcid0000-0002-0883-0610
person.identifier.ridE-5591-2014
person.identifier.scopus-author-id55767069800
relation.isAuthorOfPublication6d1bf3db-fdba-4bea-b65d-94491f841659
relation.isAuthorOfPublication.latestForDiscovery6d1bf3db-fdba-4bea-b65d-94491f841659

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Resistance to the quinolones nalidixic acid (NAL) and ciprofloxacin (CIP) and the occurrence of quinolone resistance determinants have been investigated in 300 non-typhoidal Salmonella from human origin, isolated in the years between 2004 and 2008, in 6 hospitals within Extremadura (Spain). Salmonella Enteritidis was the major serotype found among quinolone-resistant isolates, most of which were clustered by clonal analysis to a single clone, which presented D87 or S83 substitutions in GyrA. Eleven isolates presented the non-classical quinolone resistance phenotype (resistance to CIP and susceptibility to NAL), lacking mutations in the quinolone resistance determinant region of topoisomerase genes. Among them, one Salmonella Typhimurium isolate carried a qnrS1 gene in a low-molecular-weight plasmid, pQnrS1-HLR25, identical to plasmids previously found in the UK, Taiwan, and USA. The occurrence of this genetic element could represent a risk for the horizontal transmission of quinolone resistance among Enterobacteriaceae in the Iberian Peninsula.
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