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Marine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens

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dc.contributor.authorPinteus, Susete
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorSimões, Marco
dc.contributor.authorAlves, Celso
dc.contributor.authorSilva, Joana
dc.contributor.authorGaspar, Helena
dc.contributor.authorMartins, Alice
dc.contributor.authorRodrigues, Américo
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2021-08-20T14:31:14Z
dc.date.available2021-08-20T14:31:14Z
dc.date.issued2020
dc.descriptionAuthors would like to acknowledge the financial support of the Portuguese Foundation for Science and Technology (FCT) through Strategic Project UID/MAR/04292/2020 and UID/Multi/04046/2020 granted to MARE – Marine and Environmental Sciences Centre, Red2Discovery Project (PTDC/MAR-BIO/6149/2014), co-financed by COMPETE (POCI-01-0145-FEDER-016791); MARINE INVADERS Project (PTDC/BIA-CBI/31144/2017), co-financed by COMPETE (POCI-01-0145-FEDER-031144); VALORMAR (Mobilizing R&TD Programs, Portugal 2020) co-funded by COMPETE (POCI-01-0247- FEDER-024517); SAICTPAC/0019/2015 - LISBOA-01-0145-FEDER016405 Oncologia de Precisão: Terapias e Tecnologias Inovadoras (POINT4PAC) and CrossAtlantic project (PTDC/BIA-OUT/29250/ 2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250). This work was also supported by the European Union through EASME Blue Labs project AMALIA—Algae-to-MArket Lab IdeAs (EASME/EMFF/ 2016/1.2.1.4/03/SI2.750419) and the Integrated Programme of SR& TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 Program, Portugal 2020, European Union, through the European Regional Development Fund and by UIDB/04046/2020 and UIDP/04046/2020 Centre grants from FCT, Portugal (to BioISI). Susete Pinteus and Joana Silva were supported by FCT grants SFRH/BD/ 96203/2013 and SFRH/BD/103255/2014, respectively.
dc.description.abstractInfectious diseases remain one of the leading global causes of death, mainly due to the increasing number of multi-resistant microorganisms. Therefore, novel antimicrobials are continuously needed. Marine organisms have already proven to be a rich source of bioactive compounds which can be used for the development of novel pharmacological drugs. Within these, seaweeds are an important resource still underexplored. Asparagopsis armata is a marine invasive seaweed that has spread along several coastlines of the world, inducing negative pressures in marine ecosystems. Therefore, it is crucial to develop strategies to counteract their impacts. In this work, A. armata was extracted with methanol and dichloromethane (1:1) and fractionated by column chromatography with different polarity solvents, providing 8 fractions (F1-F8). All the fractions were evaluated for their antimicrobial potential against important human pathogens, namely Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enteritidis, and Candida albicans. Additionally, their capacity to inhibit biofilms formation and the effects on cytoplasmatic membrane and DNA integrity were also assessed. The most active fractions were further purified and submitted to GC–MS analysis. The results showed that A. armata produces compounds with a high inhibitory activity against S. aureus, P. aeruginosa, and C. albicans growth, possibly mediated by cytoplasmatic membrane disruption and DNA damage. GC–MS analysis suggested that the most active fractions were mainly composed of bromoditerpenes and fatty acids. The attained results point to the relevance of the invasive A. armata as a source of antimicrobial substances with broad-spectrum activity. The use of invasive species to obtain natural bioactive compounds presents a two-folded opportunity - high availability of the biological material for the extraction of bioactive compounds and, through specimen collection, the mitigation of the negative effects caused by invasive species, contributing to ecosystem integrity and sustainability.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSusete Pinteus, Marco F.L. Lemos, Marco Simões, Celso Alves, Joana Silva, Helena Gaspar, Alice Martins, Américo Rodrigues, Rui Pedrosa, Marine invasive species for high-value products' exploration – Unveiling the antimicrobial potential of Asparagopsis armata against human pathogens, Algal Research, Volume 52, 2020, 102091, ISSN 2211-9264, https://doi.org/10.1016/j.algal.2020.102091.pt_PT
dc.identifier.doi10.1016/j.algal.2020.102091pt_PT
dc.identifier.issn2211-9264
dc.identifier.urihttp://hdl.handle.net/10400.8/6129
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationBiosystems and Integrative Sciences Institute
dc.relationPRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
dc.relationBiosystems and Integrative Sciences Institute
dc.relationADD VALUE TO THE MARINE INVADERS ASPARAGOPSIS ARMATA AND SARGASSUM MUTICUM
dc.relationNeuroprotective effects of molecules isolated from Bifurcaria bifurcata and Codium tomentosum in an in vitro and in vivo Parkinson Disease model.
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S2211926420309590pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBacterial biofilmspt_PT
dc.subjectInfectious diseasespt_PT
dc.subjectMarine invaderspt_PT
dc.subjectMarine natural productspt_PT
dc.subjectMicrobial resistancept_PT
dc.subjectSeaweed bioactive compoundspt_PT
dc.titleMarine invasive species for high-value products' exploration: Unveiling the antimicrobial potential of Asparagopsis armata against human pathogenspt_PT
dc.typejournal article
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oaire.awardTitlePRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleADD VALUE TO THE MARINE INVADERS ASPARAGOPSIS ARMATA AND SARGASSUM MUTICUM
oaire.awardTitleNeuroprotective effects of molecules isolated from Bifurcaria bifurcata and Codium tomentosum in an in vitro and in vivo Parkinson Disease model.
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
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oaire.citation.titleAlgal Researchpt_PT
oaire.citation.volume52pt_PT
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