Publication
Thrombophilic risk factors for retinal vein occlusion
| dc.contributor.author | Vieira, Maria J. | |
| dc.contributor.author | Campos, António | |
| dc.contributor.author | Carmo, Anália | |
| dc.contributor.author | Arruda, Henrique | |
| dc.contributor.author | Martins, Joana | |
| dc.contributor.author | Sousa, João P. | |
| dc.date.accessioned | 2021-04-22T14:33:22Z | |
| dc.date.available | 2021-04-22T14:33:22Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | The aim is to study risk factors for retinal vein occlusion (RVO), such as thrombophilic and cardiovascular risk factors (CRF). A retrospective consecutive case series of 60 patients with RVO was made, tested for CRF, hyperhomocysteinemia, lupic anticoagulant, antiphospholipid antibody and 5 gene variants: factor V (FV) Leiden (G1691A), factor II (PT G20210A), 5,1-methylenetetra-hydrofolate reductase (MTHFR; 677 C > T and 1298 A > C), plasminogen activator inhibitor 1 (PAI-1; 4 G/5 G). More than 1 CRF were present in 36 patients (60%), which had a significantly higher mean age at diagnosis (66.7 ± 12.9 versus 59.5 ± 13.7 with ≤1 CRF, [t(57) = -2.05, p = 0.045, d = 0.54). Patients with thermolabile MTHFR forms with decreased enzyme activity (T677T or C677T/A1298C) had a significant lower mean age [57.6 ± 15.1; t (58) = 3.32; p = 0.002; d = 0.846] than patients with normal MTHFR enzyme activity (68.5 ± 10.2). Regarding CRF and thermolabile forms of MTHFR, the mean age at diagnosis could be significantly predicted [F(2,56) = 7.18; p = 0.002] by the equation: 64.8 - 10.3 × (thermolabile MTHFR) - 5.31 × ( ≤ 1CRF). Screening of MTHFR polymorphisms may be useful in younger RVO patients, particularly when multiple CRF are absent. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1038/s41598-019-55456-5 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.8/5709 | |
| dc.language.iso | eng | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.title | Thrombophilic risk factors for retinal vein occlusion | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 18972 | pt_PT |
| oaire.citation.title | Scientific Reports | pt_PT |
| oaire.citation.volume | 9 | pt_PT |
| person.familyName | Campos de Figueiredo | |
| person.givenName | António | |
| person.identifier.ciencia-id | 4F1C-D822-7CFF | |
| person.identifier.orcid | 0000-0003-0490-5889 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 175bba2d-e9a5-46df-9f0e-da7cb16f04f1 | |
| relation.isAuthorOfPublication.latestForDiscovery | 175bba2d-e9a5-46df-9f0e-da7cb16f04f1 |
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