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Functional and molecular mmune response of rainbow trout (Oncorhynchus mykiss) following challenge with Yersinia ruckeri

2022Journal article Open access
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dc.contributor.authorFajardo, Carlos
dc.contributor.authorSantos, Paulo
dc.contributor.authorPassos, Ricardo
dc.contributor.authorVaz, Mariana
dc.contributor.authorAzeredo, Rita
dc.contributor.authorMachado, Marina
dc.contributor.authorFernández-Boo, Sergio
dc.contributor.authorBaptista, Teresa
dc.contributor.authorCostas, Benjamin
dc.date.accessioned2022-05-05T12:57:41Z
dc.date.available2022-05-05T12:57:41Z
dc.date.issued2022
dc.date.updated2022-03-25T18:27:42Z
dc.descriptionFunding: This research was supported by project BE4AQUAHEALTH: RASTREIO NACIONAL DE PATOLOGIAS DE PEIXES DE AQUACULTURA: UMA APOSTA NA PREVENÇÃO (MAR-02.05.01-FEAMP-0013), funded by Mar2020 Operational Programme and the European Union through FEDER and by Fundação para a Ciência e Tecnologia (FCT), through the strategic project UID/MAR/04292/2020 granted to MARE and within the scope of UIDB/04423/2020 and UIDP/04423/2020 granted to CIIMAR. BC was supported by FCT, Portugal (2020.00290.CEECIND).pt_PT
dc.description.abstractCurrently, aquaculture production of rainbow trout (Oncorhynchus mykiss) is a multibillion dollar industry; nevertheless, the development of this sector has not been exempt from pitfalls related to the recurrent presence of pathogens of bacterial origin. This is the case of Yersinia ruckeri, the etiologic agent of the infectious pathology known as Enteric Red Mouth Disease (ERM), causing serious economic losses that can be as high as 30–70% of production. Although several studies have been performed regarding pathogen features and virulence factors, more information is needed about the host defense mechanism activation after infection. Given this perspective, this study aimed to evaluate rainbow trout’s short-term innate immune response against infection with Y. ruckeri. A series of factors linked to the innate immune response were evaluated, including determination of hematological parameters, oxidative stress biomarkers, and analysis of the expression of immunerelated genes. Results showed a significant decrease in several hematological parameters (white blood cell count, hematocrit, neutrophils, monocytes, lymphocytes, and thrombocytes) and oxidative stress indicators (SOD) between the control and infected groups. In addition, there were significant differences in the level of gene expression between infected individuals and the control group. Most of these genes (il-1b, il-8, il-10, tnf-a1, tnf-a2, socs3, mmp-9, cath, hsp-70, saa, fer, pcb) were upregulated within the first 24 h following infection. Results from this study showed more insights into the short-term immune response of rainbow trout to infection with Y. ruckeri, which may be useful for the establishment of biomarkers that may be used for the early detection of ERM.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFajardo, C.; Santos, P.; Passos, R.; Vaz, M.; Azeredo, R.; Machado, M.; Fernández-Boo, S.; Baptista, T.; Costas, B. Functional and Molecular Immune Response of Rainbow Trout (Oncorhynchus mykiss) Following Challenge with Yersinia ruckeri. Int. J. Mol. Sci. 2022, 23, 3096. https://doi.org/10.3390/ ijms23063096pt_PT
dc.identifier.doi10.3390/ijms23063096pt_PT
dc.identifier.issn1422-0067
dc.identifier.slugcv-prod-2962455
dc.identifier.urihttp://hdl.handle.net/10400.8/7107
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUID/MAR/04292/2020pt_PT
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationNutritional immunology as a tool to boost immunity and disease resistance in farmed fish
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiomarkerspt_PT
dc.subjectHematological profilept_PT
dc.subjectOxidative stresspt_PT
dc.subjectYersiniosispt_PT
dc.titleFunctional and molecular mmune response of rainbow trout (Oncorhynchus mykiss) following challenge with Yersinia ruckeript_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleNutritional immunology as a tool to boost immunity and disease resistance in farmed fish
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.00290.CEECIND%2FCP1599%2FCT0001/PT
oaire.citation.issue23pt_PT
oaire.citation.titleInternational Journal of Molecular Sciencespt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 3ed
person.familyNameFajardo Quiñones
person.familyNameSantos
person.familyNamePassos
person.familyNameVaz
person.familyNameAzeredo
person.familyNameMachado
person.familyNameBaptista
person.familyNameCostas Refojos
person.givenNameCarlos
person.givenNamePaulo
person.givenNameRicardo
person.givenNameMariana
person.givenNameRita
person.givenNameMarina
person.givenNameTeresa
person.givenNameBenjamin
person.identifierP-6662-2014
person.identifier.ciencia-id021E-83A1-B6D2
person.identifier.ciencia-idEC11-F452-DC1C
person.identifier.ciencia-idD214-203E-A62D
person.identifier.ciencia-idB81E-6A33-17FB
person.identifier.ciencia-idA61F-25C1-034A
person.identifier.ciencia-idD518-ADCF-593F
person.identifier.orcid0000-0001-9403-2211
person.identifier.orcid0000-0003-0812-4529
person.identifier.orcid0000-0003-4632-4492
person.identifier.orcid0000-0001-6064-0227
person.identifier.orcid0000-0003-2486-595X
person.identifier.orcid0000-0001-7718-5021
person.identifier.orcid0000-0003-1168-7461
person.identifier.orcid0000-0003-3758-0849
person.identifier.scopus-author-id57204562714
person.identifier.scopus-author-id56197820600
person.identifier.scopus-author-id56197798900
person.identifier.scopus-author-id23396255900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaidA61F-25C1-034A | Teresa Maria Coelho Baptista
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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