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Publication
Infection prevention and control strategies against carbapenem resistant Enterobacteriaceae: a systematic review
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Advisor(s)
Abstract(s)
Background: Antimicrobial resistance is exponentially worsening, and the spread of prevalent carbapenem resistant Enterobacteriaceae (CRE) is a major contributor to this global concern. Infection prevention and control strategies are increasingly consolidated key tools to control this worldwide problem.
Aim: To identify, collect and analyse available evidence regarding the impact of infection prevention and control strategies on prevalent CRE dissemination.
Methods: Pubmed®, Scopus® andWeb of Science® were searched systematically for articles published between 1th January 2017 and 30th June 2020, guided by the research question ‘What are the most effective and efficient strategies to prevent and
control infection/colonisation caused by Carbapenemresistant Escherichia coli and Carbapenem resistant Klebsiella pneumoniae?’.
Findings: Eleven thousand six hundred and thirty-five publications were found, but after applying the inclusion and exclusion criteria, only 30 were selected. The majority of reviewed studies (n = 24) were performed in outbreak situations, 26 studies occurred in acute care units and of those, 17 in intensive care units . From the set of implemented infection prevention and control measures, in 29 studies surveillance cultures were applied, in 23 studies patients were isolated or cohorted and, in general, all described the implementation of standard and contact precaution measures.
Conclusion: This systematic review underlines the importance of infection prevention and control strategies in CRE dissemination, standing out the need of further studies outside outbreak and intensive care units contexts. Investment increments and training and educating of all involved are also important contributors to shift this problem, but still with relevant gaps in their implementation, in all types of care units, that need to be addressed.
Description
Keywords
Infection prevention and control Antimicrobial stewardship Enterobacteriaceae Carbapenem resistant Escherichia coli Carbapenem resistant Klebsiella pneumoniae
Pedagogical Context
Citation
Santos-Marques, C., Ferreira, H., & Pereira, S.G. (2022). Infection prevention and control strategies against carbapenem resistant Enterobacteriaceae: a systematic review. Journal of Infection Prevention, 0(0), 1-19. https://doi.org/10.1177/17571774211066762
Publisher
Sage Publications