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A multimodal stimulation cell culture bioreactor for tissue engineering: A numerical modelling approach

2020Journal article Open access
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dc.contributor.authorMeneses, João
dc.contributor.authorSilva, João C.
dc.contributor.authorFernandes, Sofia R.
dc.contributor.authorDatta, Abhishek
dc.contributor.authorFerreira, Frederico Castelo
dc.contributor.authorMoura, Carla
dc.contributor.authorAmado, Sandra
dc.contributor.authorAlves, Nuno
dc.contributor.authorPascoal-Faria, Paula
dc.date.accessioned2023-04-19T13:47:47Z
dc.date.available2023-04-19T13:47:47Z
dc.date.issued2020
dc.descriptionThis research was funded by the Fundação para a Ciência e a Tecnologia (FCT) and Centro2020 through the following Projects: UIDP/04044/2020, PAMI—ROTEIRO/0328/2013 (No 022158) and Stimuli2BioScaffold— Stimuli modelling for BioScaffolds: from numerical modelling to in vitro tests co-financed by COMPETE2020 under the PT2020 programme, and supported by FCT (02/SAICT/2017). Ref. POCI-01-0145-FEDER-032554; Bone2Move—Development of “in vivo” experimental techniques and modeling methodologies for the evaluation of 4D scaffolds on bone defect in sheep model: an integrative research approach co-financed by COMPETE2020 under the PT2020 programme, and supported by FCT (02/SAICT/2017), Project nº 31146; MATIS—MATERIALS AND SUSTAINABLE INDUSTRIAL TECHNOLOGIES (CENTRO-01-0145-FEDER-000014-3362); Instituto de Biofísica e Engenharia Biomédica (IBEB) is supported by Fundação para a Ciência e Tecnologia (FCT), Portugal, under Grant n UIDB/00645/2020. Also supported by UID/BIO/04565/2020.pt_PT
dc.description.abstractThe use of digital twins in tissue engineering (TE) applications is of paramount importance to reduce the number of in vitro and in vivo tests. To pursue this aim, a novel multimodal bioreactor is developed, combining 3D design with numerical stimulation. This approach will facilitate the reproducibility between studies and the platforms optimisation (physical and digital) to enhance TE. The new bioreactor was specifically designed to be additive manufactured, which could not be reproduced with conventional techniques. Specifically, the design suggested allows the application of dual stimulation (electrical and mechanical) of a scaffold cell culture. For the selection of the most appropriate material for bioreactor manufacturing several materials were assessed for their cytotoxicity. Numerical modelling methods were then applied to the new bioreactor using one of the most appropriate material (Polyethylene Terephthalate Glycol-modified (PETG)) to find the optimal stimulation input parameters for bone TE based on two reported in vitro studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMeneses, J.; C. Silva, J.; R. Fernandes, S.; Datta, A.; Castelo Ferreira, F.; Moura, C.; Amado, S.; Alves, N.; Pascoal-Faria, P. A Multimodal Stimulation Cell Culture Bioreactor for Tissue Engineering: A Numerical Modelling Approach. Polymers 2020, 12, 940. https://doi.org/10.3390/polym12040940pt_PT
dc.identifier.doi10.3390/polym12040940pt_PT
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/10400.8/8416
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationInstitute of <biophysics and Biomedical Engineering
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/12/4/940pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCylindrical perfusion bioreactorpt_PT
dc.subjectMultimodal stimulationpt_PT
dc.subjectCytotoxicity studypt_PT
dc.subjectMaterial characterizationpt_PT
dc.subjectBone tissue engineeringpt_PT
dc.subjectFinite element analysispt_PT
dc.subjectElectrical stimulationpt_PT
dc.titleA multimodal stimulation cell culture bioreactor for tissue engineering: A numerical modelling approachpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleInstitute of <biophysics and Biomedical Engineering
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FCVT-CVT%2F31146%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00645%2F2020/PT
oaire.citation.issue4pt_PT
oaire.citation.titlePolymerspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMeneses
person.familyNameSilva
person.familyNameFernandes
person.familyNameFerreira
person.familyNameMonteiro de Moura
person.familyNameAmado
person.familyNameAlves
person.familyNamePascoal-Faria
person.givenNameJoão
person.givenNameJoão Carlos
person.givenNameSofia Rita
person.givenNameFrederico Castelo
person.givenNameCarla Sofia
person.givenNameSandra
person.givenNameNuno
person.givenNamePaula
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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