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Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysis

2024-03Journal article Open access
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dc.contributor.authorCasanova, Joao
dc.contributor.authorDuarte, Gonçalo Silva
dc.contributor.authorda Costa, Ana Gomes
dc.contributor.authorCatarino, Ana
dc.contributor.authorNave, Mónica
dc.contributor.authorAntunes, Telma
dc.contributor.authorSerra, Sofia Silvério
dc.contributor.authorDias, Sara Simões
dc.contributor.authorAbu-Rustum, Nadeem
dc.contributor.authorLima, Jorge
dc.date.accessioned2024-09-04T14:44:01Z
dc.date.available2024-09-04T14:44:01Z
dc.date.issued2024-03
dc.descriptionSupplementary data to this article can be found online at https://doi.org/10.1016/j.ygyno.2024.01.018.pt_PT
dc.descriptionFunding: This work in the context of the “Women's Health and Maternal Fetal Research Group” was partially co-financed by Hospital da Luz Lisboa under the initiative “Luz Investigação”. Dr. Abu-Rustum was supported in part by a National Cancer Institute/National Institutes of Health Cancer Center Support Grant (P30 CA008748). The funding sources were not involved in study design; collection, analysis and interpretation of data; the writing of the report; or the decision to submit the paper for publication.pt_PT
dc.description.abstractBackground. POLE mutated endometrial carcinomas may represent a subspecific type of tumors harboring a more favorable prognosis. Grade 3 (G3 or high-grade) endometrioid endometrial carcinomas remain a clinical dilemma, with some tumors behaving as the low-grade counterparts and others presenting a more aggressive behavior. Objectives. To determine the association between POLE mutational status and the overall-survival (OS) and progression-free-survival (PFS) of patients with G3endometrioidendometrial cancer(EC). Wealsoaimed todetermine the prevalence of POLE mutations in G3 endometrioid EC. Methods. We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO No: CRD4202340008). We searched the following electronic databases: PubMed/Medline, EMBASE, Cochrane Library, Scopus, and Webof Science. For time-to-event data, the effect of POLE mutation in G3 EC was described using hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Individual patient data for each study was investigated if available from the study authors. If individual patient data were not available, information regarding time-to-event outcomes was extracted usinganappropriatemethodology.OSandPFSwereanalyzed using both one-stage and two-stage approaches, the Kaplan-Meier method, and Cox-proportional hazards models. Results. This systematicreviewandmeta-analysisincluded19studieswith3092patientswhohadhighgrade endometrioid EC. Patients with POLE mutations had lower risks of death (HR = 0.36, 95% CI 0.26 to 0.50, I2 = 0%, 10 trials) and disease progression (HR = 0.31, 95% CI 0.17 to 0.57, I2 =33%,10trials).The pooled prevalence of POLE mutation was 11% (95% CI 9 to 13, I2 = 68%, 18 studies).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCasanova, J., Duarte, G. S., da Costa, A. G., Catarino, A., Nave, M., Antunes, T., Serra, S. S., Dias, S. S., Abu-Rustum, N., & Lima, J. (2024). Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysis. Gynecologic Oncology, 182, 99–107. https://doi.org/10.1016/j.ygyno.2024.01.018pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.ygyno.2024.01.018pt_PT
dc.identifier.issn0090-8258
dc.identifier.urihttp://hdl.handle.net/10400.8/10005
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0090825824000313pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEndometrial cancerpt_PT
dc.subjectEndometrioidpt_PT
dc.subjectHigh-gradept_PT
dc.subjectMeta-analysispt_PT
dc.subjectPOLEpt_PT
dc.subjectPrognosispt_PT
dc.subjectSystematic reviewpt_PT
dc.titlePrognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage107pt_PT
oaire.citation.startPage99pt_PT
oaire.citation.titleGynecologic Oncologypt_PT
oaire.citation.volume182pt_PT
person.familyNameDias
person.givenNameSara
person.identifier.ciencia-idAA1F-9375-B5E6
person.identifier.orcid0000-0001-6782-7481
person.identifier.ridI-9965-2018
person.identifier.scopus-author-id33367487300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationa49e0bc6-cfea-4033-aebf-a1ef9e4c5e7b
relation.isAuthorOfPublication.latestForDiscoverya49e0bc6-cfea-4033-aebf-a1ef9e4c5e7b

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