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The Usefulness of Inflammatory Biomarkers to Predict Anastomotic Leakage after Colorectal Surgery: Systematic Review and Meta-Analysis

2022-09Journal article Open access
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dc.contributor.authorRama, Nuno
dc.contributor.authorLages, Marlene C. C.
dc.contributor.authorG. Silva, Cândida
dc.contributor.authorMotta Lima, Patrícia
dc.contributor.authorCampos Gil, Inês
dc.contributor.authorGuarino, Maria
dc.contributor.authorOliveira, P.
dc.contributor.authorDixe, Maria
dc.contributor.authorA, Rocha
dc.contributor.authorCastro-Poças, Fernando
dc.contributor.authorPimentel, João
dc.date.accessioned2023-05-24T16:50:37Z
dc.date.available2023-05-24T16:50:37Z
dc.date.issued2022-09
dc.description.abstractAim: Anastomotic leakage (AL) is a severe postoperative complication in colorectal surgery, but its preclinical diagnosis may improve outcomes and increase anastomotic salvage. This study aimed to assess the added value of serum biomarkers for early detection of colorectal AL. Method: We performed a comprehensive literature review, and a qualitative and quantitative analysis of papers retrieved from MEDLINE, Embase, PubMed, Web of Science, Scopus and the Cochrane Library. We included all studies published before September 2021 assessing the serum biomarkers white blood cells (WBC), C-reactive protein (CRP), procalcitonin (PCT) and calprotectin (CLP) for the early diagnosis of AL. Results: Fifteen studies that evaluated three different systemic biomarkers in the context of AL were identified, including 5150 patients. Diagnostic test accuracy was estimated for CRP and PCT. On postoperative day (POD) 5, the highest AUC (87.1%) and specificity (80.2%) values were estimated for CRP. Random-effects meta-analysis and total effect sizes estimation for the biomarkers CRP, PCT and WBC were performed according to POD. The concentration of serum biomarkers is significantly higher in patients presenting AL. Regarding the qualitative analysis, there was significant heterogeneity in the inclusion of different subcategories of the consensus definition of colorectal AL in each paper’s definition. Conclusion: The serum biomarkers CRP and PCT are moderate predictors for AL, showing a high heterogeneity among the studies. Combinations of these biomarkers might improve predictive accuracy, but more studies will be necessary to conduct a quality metaregression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citation3pt_PT
dc.identifier.doi10.21614/sgo-488pt_PT
dc.identifier.eissn2601 - 1700
dc.identifier.urihttp://hdl.handle.net/10400.8/8514
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCelsius Publishing Housept_PT
dc.relation.publisherversionhttps://www.sgo-iasgo.com/article/usefulness-inflammatory-biomarkers-predict-anastomotic-leakage-after-colorectal-surgery-systematic-reviewpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectAnastomotic leakagept_PT
dc.subjectColorectalpt_PT
dc.subjectSurgerypt_PT
dc.subjectBiomarkerspt_PT
dc.subjectC-reactive proteinpt_PT
dc.subjectCalprotectinpt_PT
dc.titleThe Usefulness of Inflammatory Biomarkers to Predict Anastomotic Leakage after Colorectal Surgery: Systematic Review and Meta-Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage181pt_PT
oaire.citation.startPage169pt_PT
oaire.citation.titleSurgery, Gastroenterology and Oncologypt_PT
oaire.citation.volume27pt_PT
person.familyNamerama
person.familyNameLages
person.familyNameSilva
person.familyNameMotta Lima
person.familyNameCampos Gil
person.familyNameGuarino
person.familyNameOliveira
person.familyNameDixe
person.familyNameRocha
person.familyNameCastro-Poças
person.familyNamePimentel
person.givenNamenuno
person.givenNameMarlene
person.givenNameCândida
person.givenNamePatrícia
person.givenNameInês
person.givenNameMaria Pedro
person.givenNamePedro
person.givenNameMaria dos Anjos
person.givenNameAnabela
person.givenNameFernando
person.givenNameJoão
person.identifierR-000-F2N
person.identifier794059
person.identifier.ciencia-idE012-FE6B-9A38
person.identifier.ciencia-idC613-4639-10A8
person.identifier.ciencia-idD513-D305-7FD1
person.identifier.ciencia-idF21A-BD01-2D52
person.identifier.ciencia-id6C11-D7C8-DD95
person.identifier.ciencia-idDB15-BD76-2B75
person.identifier.orcid0000-0002-1572-2239
person.identifier.orcid0000-0002-7389-6368
person.identifier.orcid0000-0002-7092-1169
person.identifier.orcid0000-0002-6427-8955
person.identifier.orcid0000-0001-5008-2129
person.identifier.orcid0000-0001-6079-1105
person.identifier.orcid0000-0002-2470-0795
person.identifier.orcid0000-0001-9035-8548
person.identifier.orcid0000-0001-5000-5369
person.identifier.orcid0000-0002-2268-9107
person.identifier.orcid0000-0003-1908-8607
person.identifier.ridB-5594-2015
person.identifier.ridB-9257-2018
person.identifier.ridF-6095-2015
person.identifier.scopus-author-id55429869600
person.identifier.scopus-author-id56348477000
person.identifier.scopus-author-id7102098106
person.identifier.scopus-author-id55885797900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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