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Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives

2024-04-05Journal article Open access
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dc.contributor.authorConde, Silvia V.
dc.contributor.authorSacramento, Joana F.
dc.contributor.authorZinno, Ciro
dc.contributor.authorMazzoni, Alberto
dc.contributor.authorMicera, Silvestro
dc.contributor.authorGuarino, Maria P.
dc.date.accessioned2024-09-04T15:03:47Z
dc.date.available2024-09-04T15:03:47Z
dc.date.issued2024-04-05
dc.descriptionThis article is part of the Research Topic Bioelectronic Medicines – New Frontiers in Autonomic Neuromodulation, Volume III.pt_PT
dc.descriptionFunding: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. JS is supported with a contract from the Portuguese Foundation for Science and Technology (CEEC IND/02428/2018). MG is supported by a contract from the Portuguese Foundation for Science and Technology (CEECINST/00051/2018) and (UIDP/05704/2020).pt_PT
dc.description.abstractBioelectronic medicine are an emerging class of treatments aiming to modulate body nervous activity to correct pathological conditions and restore health. Recently, it was shown that the high frequency electrical neuromodulation of the carotid sinus nerve (CSN), a small branch of the glossopharyngeal nerve that connects the carotid body (CB) to the brain, restores metabolic function in type 2 diabetes (T2D) animal models highlighting its potential as a new therapeutic modality to treat metabolic diseases in humans. In this manuscript, we review the current knowledge supporting the use of neuromodulation of the CSN to treat T2D and discuss the future perspectives for its clinical application. Firstly, we review in a concise manner the role of CB chemoreceptors and of CSN in the pathogenesis of metabolic diseases. Secondly, we describe the findings supporting the potential therapeutic use of the neuromodulation of CSN to treat T2D, as well as the feasibility and reversibility of this approach. A third section is devoted to point up the advances in the neural decoding of CSN activity, in particular in metabolic disease states, that will allow the development of closed-loop approaches to deliver personalized and adjustable treatments with minimal side effects. And finally, we discuss the findings supporting the assessment of CB activity in metabolic disease patients to screen the individuals that will benefit therapeutically from this bioelectronic approach in the future.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationConde SV, Sacramento JF, Zinno C, Mazzoni A, Micera S and Guarino MP (2024). Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives. Front. Neurosci. 18:1378473. doi: 10.3389/fnins.2024.1378473pt_PT
dc.identifier.doihttps://doi.org/10.3389/fnins.2024.1378473pt_PT
dc.identifier.eissn1662-453X
dc.identifier.issn1662-4548
dc.identifier.urihttp://hdl.handle.net/10400.8/10007
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationNot Available
dc.relationNot Available
dc.relationCenter for Innovative Care and Health Technology
dc.relation.publisherversionhttps://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1378473/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectbioelectronic medicinept_PT
dc.subjectcarotid bodypt_PT
dc.subjectcarotid sinus nervept_PT
dc.subjectneuromodulationpt_PT
dc.subjecttype 2 diabetespt_PT
dc.titleBioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectivespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F02428%2F2018%2FCP1564%2FCT0018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00051%2F2018%2FCP1566%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F05704%2F2020/PT
oaire.citation.titleFrontiers in Neurosciencept_PT
oaire.citation.volume18pt_PT
oaire.fundingStreamCEEC IND 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGuarino
person.givenNameMaria Pedro
person.identifier.ciencia-idF21A-BD01-2D52
person.identifier.orcid0000-0001-6079-1105
person.identifier.ridB-5594-2015
person.identifier.scopus-author-id56348477000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoveryf163d4df-1e45-4278-affa-5994f206becf
relation.isProjectOfPublication3e8316b1-2981-4c4c-9ecf-84d88654dcfa
relation.isProjectOfPublication79a941dc-2813-4f89-850b-4228ff5224cc
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