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Evaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminants

2021Journal article Open access
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dc.contributor.authorPires, Vanessa
dc.contributor.authorNovais, Sara C.
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorFonseca, Vanessa
dc.contributor.authorDuarte, Bernardo
dc.date.accessioned2021-08-09T14:54:16Z
dc.date.available2021-08-09T14:54:16Z
dc.date.issued2021
dc.descriptionThe authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research via project grants PTDC/MAR-EST/3048/2014 (BIOPHARMA), PTDC/CTAAMB/30056/2017 (OPTOX), UIDB/04292/2020 and UID/MULTI/04046/2019. Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. B. Duarte and V. F. Fonseca were supported by researcher contracts (CEECIND/00511/2017 and DL57/2016/CP1479/CT0024).
dc.description.abstractWorldwide anthropogenic activities result in the production and release of potentially damaging toxic pollutants into ecosystems, thereby jeopardizing their health and continuity. Research studies and biomonitoring programs attend to this emerging problematic by applying and developing statistically relevant indexes that integrate complex biomarker response data to provide a holistic approach, reflecting toxically induced alterations at the organism or population level. Ultimately, indexes allow simple result communications, enhancing policy makers understanding, and contributing to better resource and environmental managing policies. In this study three indexes, the integrated biomarker response index (IBR), the bioeffects assessment index (BAI) and principal components analysis (PCA), were evaluated for their sensitivity in revealing toxically induced stress patterns in cells of the diatom Phaeodactylum tricornutum under contaminant exposure. The set of biomarkers selected for index construction comprised the anti-oxidant enzymes APX, CAT and SOD, and the lipid peroxidation marker TBARS. Several significant correlations with the applied concentration gradients were noticed for all indexes, although IBR excelled for its reliability in delivering statistically significant dose-response patterns for four out of the five tested compounds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPires, V.L.; Novais, S.C.; Lemos, M.F.L.; Fonseca, V.F.; Duarte, B. Evaluation of Multivariate Biomarker Indexes Application in Ecotoxicity Tests with Marine Diatoms Exposed to Emerging Contaminants. Appl. Sci. 2021, 11, 3878. https://doi.org/10.3390/ app11093878pt_PT
dc.identifier.doi10.3390/ app11093878pt_PT
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.8/6048
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMarine and Environmental Sciences Centre
dc.relationBiosystems & Integrative Sciences Institute
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/11/9/3878/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidant enzymespt_PT
dc.subjectPharmaceutical residuespt_PT
dc.subjectPesticidespt_PT
dc.subjectDetergentspt_PT
dc.subjectIntegrative indexespt_PT
dc.titleEvaluation of multivariate biomarker indexes application in ecotoxicity tests with marine diatoms exposed to emerging contaminantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleBiosystems & Integrative Sciences Institute
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR-EST%2F3048%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04046%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00511%2F2017%2FCP1387%2FCT0039/PT
oaire.citation.titleApplied sciencespt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
person.familyNameLeal Pires
person.familyNameNovais
person.familyNameLemos
person.familyNameFonseca
person.familyNameDuarte
person.givenNameVanessa
person.givenNameSara
person.givenNameMarco
person.givenNameVanessa
person.givenNameBernardo
person.identifier996337
person.identifier553991
person.identifierhttps://scholar.google.com/citations?user=uAWV7zIAAAAJ&hl=pt-PT&oi=ao
person.identifier.ciencia-idFC1F-439B-10A9
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person.identifier.ciencia-id1E11-AE01-98EC
person.identifier.ciencia-id731E-093F-D4C8
person.identifier.orcid0000-0002-8162-6130
person.identifier.orcid0000-0003-1306-3396
person.identifier.orcid0000-0001-9887-1864
person.identifier.orcid0000-0002-6374-1194
person.identifier.orcid0000-0003-1914-7435
person.identifier.ridA-9032-2012
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person.identifier.ridB-3696-2012
person.identifier.scopus-author-id23025463300
person.identifier.scopus-author-id7006042884
person.identifier.scopus-author-id14021110600
person.identifier.scopus-author-id20734149900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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