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Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds

2021-03-05Journal article Open access
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dc.contributor.authorPires, T.
dc.contributor.authorSantos, J.
dc.contributor.authorRuben, R. B.
dc.contributor.authorGouveia, B.
dc.contributor.authorCastro, A. P. G.
dc.contributor.authorFernandes, P. R.
dc.date.accessioned2023-03-17T18:43:32Z
dc.date.available2023-03-17T18:43:32Z
dc.date.issued2021-03-05
dc.description.abstractBone Tissue Engineering has been focusing on improving the current methods for bone repair, being the use of scaffolds presented as an upgrade to traditional surgery techniques. Scaffolds are artificially porous matrices, meant to promote cell seeding and proliferation, being these properties influenced by the permeability of the structure. This work employed experimental pressure drop tests and Computational Fluid Dynamics models to assess permeability (and fluid streamlines) within different triply periodic minimal surfaces scaffold geometries (Schwarz D, Gyroid and Schwarz P). The pressure outputs from the computational analysis presented a good correlation with the experimental results, with R2 equal to 0.903; they have also shown that a lower porosity may not mean a lower permeability if the geometry is altered, such as the difference between 60% porous Gyroid scaffolds (8.1*10-9 mm2) and 70% porous Schwarz D scaffolds (7.1*10-9 mm2). Fluid streamlines revealed how the Gyroid geometries are the most appropriate design for most bone tissue engineering applications, due to their consistent fluid permeation, followed by Schwarz D. The Schwarz P geometries have shown flat streamlines and significant variation of the permeability with the porosity (an increase of 10% in their porosity lead to an increase in the permeability from 5.1*10-9 mm2 to 11.7*10-9 mm2), which would imply a poor environment for cell seeding and proliferation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTiago Pires, Jorge Santos, Rui B. Ruben, Bárbara P. Gouveia, André P.G. Castro, Paulo R. Fernandes, Numerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffolds, Journal of Biomechanics, Volume 117, 2021, 110263, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2021.110263pt_PT
dc.identifier.doi10.1016/j.jbiomech.2021.110263pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.8/8252
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectComputational fluid dynamicspt_PT
dc.subjectTriply periodic minimal surfacespt_PT
dc.subjectPermeabilitypt_PT
dc.subjectScaffoldspt_PT
dc.subjectBone tissue engineeringpt_PT
dc.titleNumerical-experimental analysis of the permeability-porosity relationship in triply periodic minimal surfaces scaffoldspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Biomechanicspt_PT
oaire.citation.volumeVol. 117pt_PT
person.familyNameRuben
person.givenNameRui
person.identifier46426
person.identifier.ciencia-id0A14-A279-7C05
person.identifier.orcid0000-0002-5407-0579
person.identifier.ridM-1119-2014
person.identifier.scopus-author-id7103127401
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione69b86a2-a7dc-433d-94cb-0f3196fdc670
relation.isAuthorOfPublication.latestForDiscoverye69b86a2-a7dc-433d-94cb-0f3196fdc670

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