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Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses

2020Journal article Restricted access
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dc.contributor.authorRodrigues, Flávia S. C.
dc.contributor.authorCampos, António
dc.contributor.authorMartins, João
dc.contributor.authorAmbrósio, António Francisco
dc.contributor.authorCampos, Elisa J.
dc.date.accessioned2022-02-04T14:33:04Z
dc.date.available2022-02-04T14:33:04Z
dc.date.issued2020
dc.description.abstractVision is the most dominant of our senses, and it is crucial in every stage of our lives. Ocular diseases, regardless of whether they cause vision impairment or not, lead to personal and financial hardships. The anatomy and physiology of the eye strongly limit the efficacy of current ocular drug delivery strategies. Nanotechnology has been the ground for the development of powerful strategies in several fields, namely in medicine. This review highlights emerging nanotechnology-based solutions for improving ocular drug delivery and thus the bioavailability and efficacy of drugs. We focus our review on ambitious but promising approaches currently emerging to leverage the efficacy of nanoparticle-based systems in ocular therapy: (i) light-responsive nanoparticles, which enable spatiotemporal control of drug release; (ii) mesoporous silica nanoparticles, which offer high surface area-to-volume ratio, simple surface modification, good biocompatibility, and improved bioavailability; and (iii) contact lenses, which serve as a compliant method of nanoparticles use and as drug delivery systems for the treatment of ocular diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRodrigues FSC, Campos A, Martins J, Ambrósio AF, Campos EJ. Emerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lenses. ACS Biomater Sci Eng. 2020 Dec 14;6(12):6587-6597. doi: 10.1021/acsbiomaterials.0c01347pt_PT
dc.identifier.doi10.1021/acsbiomaterials.0c01347pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.8/6598
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Chemical Societypt_PT
dc.relationUIDB/ 04539/2020pt_PT
dc.relationCNC. IBILI
dc.relation.ispartofseries12;
dc.subjectNanoparticlespt_PT
dc.subjectContact lenspt_PT
dc.subjectOcular therapypt_PT
dc.subjectDrug deliverypt_PT
dc.titleEmerging Trends in Nanomedicine for Improving Ocular Drug Delivery: Light-Responsive Nanoparticles, Mesoporous Silica Nanoparticles, and Contact Lensespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCNC. IBILI
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FNEU%2F04539%2F2019/PT
oaire.citation.endPage6597pt_PT
oaire.citation.startPage6587pt_PT
oaire.citation.titleACS Biomaterials Science & Engineeringpt_PT
oaire.citation.volume6pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCampos de Figueiredo
person.givenNameAntónio
person.identifier.ciencia-id4F1C-D822-7CFF
person.identifier.orcid0000-0003-0490-5889
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication175bba2d-e9a5-46df-9f0e-da7cb16f04f1
relation.isAuthorOfPublication.latestForDiscovery175bba2d-e9a5-46df-9f0e-da7cb16f04f1
relation.isProjectOfPublication67eefb09-f78f-4fd7-aa40-f86323a1d407
relation.isProjectOfPublication.latestForDiscovery67eefb09-f78f-4fd7-aa40-f86323a1d407

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