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Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells

2021-03-01Artigo científico Acesso restrito
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datacite.subject.fosCiências Naturais::Outras Ciências Naturais
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorBeeby, Ellie
dc.contributor.authorMagalhães, Mariana
dc.contributor.authorLemos, Marco F. L.
dc.contributor.authorPires, Isabel M.
dc.contributor.authorCabral, Célia
dc.date.accessioned2026-03-16T14:29:03Z
dc.date.available2026-03-16T14:29:03Z
dc.date.issued2021-03-01
dc.description.abstractEthnopharmacological relevance: The past few years have witnessed an increasing interest in essential oils (EOs) as potential therapeutic agents against a wide variety of pathologies, including cancer. EOs extracted from Ridolfia segetum (L.) Moris (R. segetum) are a clear example of a phytoproduct with therapeutic applications, as it is widely used in traditional medicine due to its antioxidant and anti-inflammatory properties, and these properties were already validated by previous studies. Although, it is well established that inflammation is a key hallmark of cancer, with a key role promoting tumorigenesis, and being chronic inflammation often associated with tumorigenic processes, there are no previous studies regarding the assessment of the antitumoural potential of R. segetum EOs. Aim of the study: The present study intends to be the first to evaluate the antitumoural proprieties of R. segetum EO phytoproducts in cancer cell models. Materials and methods: For this, R. segetum EOs were extracted from plants collected at either flowering (RS_Fl) or fruiting (RS_Fr) stage. The impact on proliferation and viability of treatment with R. segetum EO extracts was assessed using in vitro 2D and 3D models. Results: Both R. segetum EOs presented effective antiproliferative/viability effects, evidence noted by low IC50 values in 2D models, and significant reduction of spheroid size in 3D in vitro models. Mechanistically, treatment with R. segetum EOs was associated with an altered G1 (associated with p21 stabilisation), and subsequent induction of apoptosis. Conclusions: Overall, these results indicate that R. segetum EOs have potential as suitable antitumoural therapeutic agents.eng
dc.description.sponsorshipThis work was supported through Higher Education Funding Council for England (HEFCE) funding provided by the University of Hull (IMP and EB), by Fundação para a Ciência e Tecnologia (FCT) Strategic Projects UID/MAR/04292/2013 grant to MARE; UID/NEU/04539/2013 and UID/NEU/04539/2019 grant to CNC.IBILI, UIDB/04539/2020 and UIDP/04539/2020 grant to CIBB; and SAICTPAC/0019/2015—LISBOA-01-0145-FEDER-016405 - Oncologia de Precisão: Terapias e Tecnologias Inovadoras (POINT4PAC). The project was also partially funded by the Integrated Programme of SR&TD “SmartBioR” (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund.
dc.identifier.citationEllie Beeby, Mariana Magalhães, Marco F.L. Lemos, Isabel M. Pires, Célia Cabral, Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cells, Journal of Ethnopharmacology, Volume 267, 2021, 113515, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2020.113515.
dc.identifier.doi10.1016/j.jep.2020.113515
dc.identifier.eissn1872-7573
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/10400.8/15882
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0378874120334012?via%3Dihub
dc.relation.ispartofJournal of Ethnopharmacology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAntitumour activity
dc.subjectEssential oil
dc.subjectNatural products
dc.subjectRidolfia segetum
dc.titleCytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cellseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUID/MAR/04292/2013
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAR%2F04292%2F2013/PT
oaire.citation.endPage8
oaire.citation.startPage1
oaire.citation.titleJournal of Ethnopharmacology
oaire.citation.volume267
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLemos
person.givenNameMarco
person.identifier996337
person.identifier.ciencia-id971F-ACCA-C0D1
person.identifier.orcid0000-0001-9887-1864
person.identifier.ridF-7951-2011
person.identifier.scopus-author-id7006042884
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationf21e5540-df76-43e9-ad64-93edd70da1f1
relation.isAuthorOfPublication.latestForDiscoveryf21e5540-df76-43e9-ad64-93edd70da1f1
relation.isProjectOfPublicationeb4d28f0-4a5c-4473-a445-aef6f6cb124d
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Ethnopharmacological relevance: The past few years have witnessed an increasing interest in essential oils (EOs) as potential therapeutic agents against a wide variety of pathologies, including cancer. EOs extracted from Ridolfia segetum (L.) Moris (R. segetum) are a clear example of a phytoproduct with therapeutic applications, as it is widely used in traditional medicine due to its antioxidant and anti-inflammatory properties, and these properties were already validated by previous studies. Although, it is well established that inflammation is a key hallmark of cancer, with a key role promoting tumorigenesis, and being chronic inflammation often associated with tumorigenic processes, there are no previous studies regarding the assessment of the antitumoural potential of R. segetum EOs. Aim of the study: The present study intends to be the first to evaluate the antitumoural proprieties of R. segetum EO phytoproducts in cancer cell models. Materials and methods: For this, R. segetum EOs were extracted from plants collected at either flowering (RS_Fl) or fruiting (RS_Fr) stage. The impact on proliferation and viability of treatment with R. segetum EO extracts was assessed using in vitro 2D and 3D models. Results: Both R. segetum EOs presented effective antiproliferative/viability effects, evidence noted by low IC50 values in 2D models, and significant reduction of spheroid size in 3D in vitro models. Mechanistically, treatment with R. segetum EOs was associated with an altered G1 (associated with p21 stabilisation), and subsequent induction of apoptosis. Conclusions: Overall, these results indicate that R. segetum EOs have potential as suitable antitumoural therapeutic agents.
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