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- The Physical Activity Enjoyment Scale (Paces) as a Two-Dimensional Scale: Exploratory and Invariance AnalysisPublication . Rodrigues, Filipe; Forte, Pedro; Teixeira, Diogo Santos; Cid, Luis; Monteiro, DiogoThe current study aims to examine the Physical Activity Enjoyment Scale (PACES) as a two-dimensional scale assessing two correlated but distinct dimensions of enjoyment. In total, 277 individuals (female = 108) aged between 18 and 53 years (M = 35.66; SD = 7.42) participated in the study. The unidimensional model solution displayed good fit. However, the exploratory structural equation modelling specification considering two correlated but distinct dimensions of enjoyment showed a better fit. This study was the first attempt to examine the possible existence of two dimensions within the eight-item PACES measure. The distinct aspect of the current research is to emphasize the complex and constant process of instrument validation. Scales should be viewed as a continuous process, and future methodological procedures will increase our understanding of instrument examination with more innovative statistical approaches.
- Clinical Decision-Making in Nursing Scale (CDMNS-PT©) in nursing students: Translation and validationPublication . Duarte, Hugo Miguel Santos; Dixe, Maria dos Anjos Coelho Rodriguesto validate, for the Portuguese population, the Clinical Decision-Making Nursing Scale© (CDMNS©). Methods: this methodological study involved 496 nursing students who filled in a questionnaire created using sociodemographic and academic data, and the scale to evaluate the making of decisions in nursing. Results: the confirmatory factorial analysis showed that the adjustment of the factorial structure has good quality, being made up by three factors (X2/gl = 2.056; GFI = 0.927; CFI = 0.917; RMSEA = 0.046; RMR = 0.039; SRMR = 0.050). For the scale to be reliable, it had to include only the reliability of the scale required it to be constituted by 23 items, with correlation values that varied from 0.184 and 0.610, and a global Cronbach’s Alpha of 0.851, which showed its good reliability. Conclusions: the CDMNS-PT© is valid and reliable, showing a high potential to be used in clinical practice and investigation.
- Cytotoxic effects of Ridolfia segetum (L.) Moris phytoproducts in cancer cellsPublication . Beeby, Ellie; Magalhães, Mariana; Lemos, Marco F. L.; Pires, Isabel M.; Cabral, CéliaEthnopharmacological relevance: The past few years have witnessed an increasing interest in essential oils (EOs) as potential therapeutic agents against a wide variety of pathologies, including cancer. EOs extracted from Ridolfia segetum (L.) Moris (R. segetum) are a clear example of a phytoproduct with therapeutic applications, as it is widely used in traditional medicine due to its antioxidant and anti-inflammatory properties, and these properties were already validated by previous studies. Although, it is well established that inflammation is a key hallmark of cancer, with a key role promoting tumorigenesis, and being chronic inflammation often associated with tumorigenic processes, there are no previous studies regarding the assessment of the antitumoural potential of R. segetum EOs. Aim of the study: The present study intends to be the first to evaluate the antitumoural proprieties of R. segetum EO phytoproducts in cancer cell models. Materials and methods: For this, R. segetum EOs were extracted from plants collected at either flowering (RS_Fl) or fruiting (RS_Fr) stage. The impact on proliferation and viability of treatment with R. segetum EO extracts was assessed using in vitro 2D and 3D models. Results: Both R. segetum EOs presented effective antiproliferative/viability effects, evidence noted by low IC50 values in 2D models, and significant reduction of spheroid size in 3D in vitro models. Mechanistically, treatment with R. segetum EOs was associated with an altered G1 (associated with p21 stabilisation), and subsequent induction of apoptosis. Conclusions: Overall, these results indicate that R. segetum EOs have potential as suitable antitumoural therapeutic agents.