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Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver

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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg04:Educação de Qualidade
datacite.subject.sdg17:Parcerias para a Implementação dos Objetivos
dc.contributor.authorSacramento, Joana F.
dc.contributor.authorRibeiro, Maria J.
dc.contributor.authorRodrigues, Tiago
dc.contributor.authorOlea, Elena
dc.contributor.authorMelo, Bernardete F.
dc.contributor.authorGuarino, Maria P.
dc.contributor.authorFonseca-Pinto, Rui
dc.contributor.authorFerreira, Cristiana R.
dc.contributor.authorCoelho, Joana
dc.contributor.authorObeso, Ana
dc.contributor.authorSeiça, Raquel
dc.contributor.authorMatafome, Paulo
dc.contributor.authorConde, Silvia V.
dc.date.accessioned2026-01-20T15:18:24Z
dc.date.available2026-01-20T15:18:24Z
dc.date.issued2017
dc.description.abstractAims/hypothesis: We recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in animal models of the metabolic syndrome. Additionally, we have demonstrated that CB activity is increased in animal models of insulin resistance, and that carotid sinus nerve (CSN) resection prevents the development of insulin resistance and arterial hypertension induced by high-energy diets. Here, we tested whether the functional abolition of CB by CSN transection would reverse pre-established insulin resistance, dyslipidaemia, obesity, autonomic dysfunction and hypertension in animal models of the metabolic syndrome. The effect of CSN resection on insulin signalling pathways and tissue-specific glucose uptake was evaluated in skeletal muscle, adipose tissue and liver. Methods: Experiments were performed in male Wistar rats submitted to two high-energy diets: a high-fat diet, representing a model of insulin resistance, hypertension and obesity, and a high-sucrose diet, representing a lean model of insulin resistance and hypertension. Half of each group was submitted to chronic bilateral resection of the CSN. Age-matched control rats were also used. Results: CSN resection normalised systemic sympathetic nervous system activity and reversed weight gain induced by high-energy diets. It also normalised plasma glucose and insulin levels, insulin sensitivity lipid profile, arterial pressure and endothelial function by improving glucose uptake by the liver and perienteric adipose tissue. Conclusions/interpretation: We concluded that functional abolition of CB activity restores insulin sensitivity and glucose homeostasis by positively affecting insulin signalling pathways in visceral adipose tissue and liver.eng
dc.description.sponsorshipThis study was supported by the Portuguese Foundation for Science and Technology (FCT), grants EXPL/NEU-SCC/2183 and Pest-C/SAU/UI3282/2011, grant BFU2015-70616-R (MINECO/FEDER, UE) (Spain) and grant CIBER CB06/06/0050 from the Institute of Health Carlos III (Spain). JFS and MJR are supported by PhD Grants from FCT, PD/BD/105890/2014 and SFR/BD/88983/2012, respectively.
dc.identifier.citationSacramento JF, Ribeiro MJ, Rodrigues T, Olea E, Melo BF, Guarino MP, Fonseca-Pinto R, Ferreira CR, Coelho J, Obeso A, Seiça R, Matafome P, Conde SV. Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver. Diabetologia. 2017 Jan;60(1):158-168. doi: 10.1007/s00125-016-4133-y
dc.identifier.doi10.1007/s00125-016-4133-y
dc.identifier.issn0012-186X
dc.identifier.issn1432-0428
dc.identifier.urihttp://hdl.handle.net/10400.8/15419
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Science and Business Media LLC
dc.relationModulation of carotid body activity as a therapeutic intervention in metabolic diseases.
dc.relationPest-C/SAU/UI3282/2011
dc.relationBFU2015-70616-R
dc.relationCIBER CB06/06/0050
dc.relationPD/BD/105890/2014
dc.relationSFR/BD/88983/2012
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s00125-016-4133-y
dc.relation.ispartofDiabetologia
dc.rights.uriN/A
dc.subjectAdipose tissue
dc.subjectCarotid sinus nerve
dc.subjectGlucose homeostasis
dc.subjectInsulin sensitivity
dc.subjectLiver
dc.titleFunctional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the livereng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleModulation of carotid body activity as a therapeutic intervention in metabolic diseases.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F105890%2F2014/PT
oaire.citation.endPage168
oaire.citation.issue1
oaire.citation.startPage158
oaire.citation.titleDiabetologia
oaire.citation.volume60
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGuarino
person.familyNameFonseca-Pinto
person.givenNameMaria Pedro
person.givenNameRui
person.identifier.ciencia-idF21A-BD01-2D52
person.identifier.ciencia-id681D-C547-B184
person.identifier.orcid0000-0001-6079-1105
person.identifier.orcid0000-0001-6774-5363
person.identifier.ridB-5594-2015
person.identifier.ridK-9449-2014
person.identifier.scopus-author-id56348477000
person.identifier.scopus-author-id26039086400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationf163d4df-1e45-4278-affa-5994f206becf
relation.isAuthorOfPublication7eb9d123-1800-4afd-a2f6-91043353011b
relation.isAuthorOfPublication.latestForDiscoveryf163d4df-1e45-4278-affa-5994f206becf
relation.isProjectOfPublication8d184299-84d1-4918-9ab6-1ae18bb57139
relation.isProjectOfPublication.latestForDiscovery8d184299-84d1-4918-9ab6-1ae18bb57139

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