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Blood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulation

2022-01-10Journal article Open access
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dc.contributor.authorConde, Silvia V
dc.contributor.authorSacramento, Joana F.
dc.contributor.authorMelo, Bernardete F.
dc.contributor.authorFonseca-Pinto, Rui
dc.contributor.authorRomero-Ortega, Mario I.
dc.contributor.authorGuarino, Maria Pedro
dc.date.accessioned2023-06-15T09:38:56Z
dc.date.available2023-06-15T09:38:56Z
dc.date.issued2022-01-10
dc.description.abstractChronic carotid sinus nerve (CSN) electrical modulation through kilohertz frequency alternating current improves metabolic control in rat models of type 2 diabetes, underpinning the potential of bioelectronic modulation of the CSN as a therapeutic modality for metabolic diseases in humans. The CSN carries sensory information from the carotid bodies, peripheral chemoreceptor organs that respond to changes in blood biochemical modifications such as hypoxia, hypercapnia, acidosis, and hyperinsulinemia. In addition, the CSN also delivers information from carotid sinus baroreceptors—mechanoreceptor sensory neurons directly involved in the control of blood pressure—to the central nervous system. The interaction between these powerful reflex systems—chemoreflex and baroreflex—whose sensory receptors are in anatomical proximity, may be regarded as a drawback to the development of selective bioelectronic tools to modulate the CSN. Herein we aimed to disclose CSN influence on cardiovascular regulation, particularly under hypoxic conditions, and we tested the hypothesis that neuromodulation of the CSN, either by electrical stimuli or surgical means, does not significantly impact blood pressure. Experiments were performed in Wistar rats aged 10–12 weeks. No significant effects of acute hypoxia were observed in systolic or diastolic blood pressure or heart rate although there was a significant activation of the cardiac sympathetic nervous system. We conclude that chemoreceptor activation by hypoxia leads to an expected increase in sympathetic activity accompanied by compensatory regional mechanisms that assure blood flow to regional beds and maintenance of hemodynamic homeostasis. Upon surgical denervation or electrical block of the CSN, the increase in cardiac sympathetic nervous system activity in response to hypoxia was lost, and there were no significant changes in blood pressure in comparison to control animals. We conclude that the responses to hypoxia and vasomotor control short-term regulation of blood pressure are dissociated in terms of hypoxic response but integrated to generate an effector response to a given change in arterial pressure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationConde SV, Sacramento JF, Melo BF, Fonseca-Pinto R, Romero-Ortega MI and Guarino MP (2022) Blood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulation. Front. Neurosci. 15:725751. doi: 10.3389/fnins.2021.725751pt_PT
dc.identifier.doihttps://doi.org/10.3389/fnins.2021.725751pt_PT
dc.identifier.eissn1662-453X
dc.identifier.issn1662-4548
dc.identifier.urihttp://hdl.handle.net/10400.8/8599
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationNot Available
dc.relationTargeting the carotid bodies to treat obesity
dc.relationCenter for Innovative Care and Health Technology
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fnins.2021.725751/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCarotid bodypt_PT
dc.subjectCarotid sinus nervept_PT
dc.subjectHypoxiapt_PT
dc.subjectBlood pressurept_PT
dc.subjectNeuromodulationpt_PT
dc.titleBlood Pressure Regulation by the Carotid Sinus Nerve: Clinical Implications for Carotid Body Neuromodulationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleTargeting the carotid bodies to treat obesity
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F02428%2F2018%2FCP1564%2FCT0018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F128336%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.citation.startPage725751pt_PT
oaire.citation.titleFrontiers in Neurosciencept_PT
oaire.citation.volume15pt_PT
oaire.fundingStreamCEEC IND 2018
oaire.fundingStream6817 - DCRRNI ID
person.familyNameVilares Conde
person.familyNameSacramento
person.familyNameMelo
person.familyNameFonseca-Pinto
person.familyNameRomero-Ortega
person.familyNameGuarino
person.givenNameSilvia
person.givenNameJoana F.
person.givenNameBernardete
person.givenNameRui
person.givenNameMario
person.givenNameMaria Pedro
person.identifier154176
person.identifier.ciencia-id561E-CF29-600A
person.identifier.ciencia-id051A-D3AD-AEAD
person.identifier.ciencia-idF01C-821E-FA56
person.identifier.ciencia-id681D-C547-B184
person.identifier.ciencia-idF21A-BD01-2D52
person.identifier.orcid0000-0002-5920-5700
person.identifier.orcid0000-0002-0853-4918
person.identifier.orcid0000-0002-5065-5385
person.identifier.orcid0000-0001-6774-5363
person.identifier.orcid0000-0003-2576-2629
person.identifier.orcid0000-0001-6079-1105
person.identifier.ridK-9449-2014
person.identifier.ridT-2520-2018
person.identifier.ridB-5594-2015
person.identifier.scopus-author-id7004283202
person.identifier.scopus-author-id55354438100
person.identifier.scopus-author-id26039086400
person.identifier.scopus-author-id7202430739
person.identifier.scopus-author-id56348477000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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