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Lanthanide-based organic salts: Synthesis, characterization, and cytotoxicity studies

2023Journal article Open access
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dc.contributor.authorForte, Andreia
dc.contributor.authorGago, Sandra
dc.contributor.authorAlves, Celso
dc.contributor.authorSilva, Joana
dc.contributor.authorPedrosa, Rui
dc.contributor.authorLaia, César A.T.
dc.contributor.authorMarrucho, Isabel M.
dc.contributor.authorBranco, Luis C.
dc.date.accessioned2023-11-29T10:41:59Z
dc.date.available2023-11-29T10:41:59Z
dc.date.issued2023
dc.descriptionThis work was supported by Fundação para a Ciência e a Tecnologia through projects (PEst-C/LA0006/2013, PTCD/CTM-NAN/120658/2010, two contracts under Investigador FCT (L. C. Branco and I. M. Marrucho), a doctoral fellowship Andreia Forte (PD/BD/109625/2015), and by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/MAR/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and Solchemar company.pt_PT
dc.description.abstractThe formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. The magnetic moments obtained for the Gd(III) salts were, as expected, smaller than those obtained for the Tb(III)-based compounds. The values for Gd(III) and Tb(III) magnetic salts are in the range of 6.55–7.30 MB and 8.22–9.34 MB, respectively. It is important to note a correlation between the magnetic moments obtained for lanthanides, and the structural features of the cation. The cytotoxicity of lanthanide-based salts was also evaluated using 3T3, 293T, Caco2, and HepG2 cells, and it was revealed that most of the prepared compounds are not toxic.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationForte, A.; Gago, S.; Alves, C.; Silva, J.; Alves, J.; Pedrosa, R.; Laia, C.A.T.; Marrucho, I.M.; Branco, L.C. Lanthanide-Based Organic Salts: Synthesis, Characterization, and Cytotoxicity Studies. Molecules 2023, 28, 7152. https://doi.org/10.3390/molecules28207152pt_PT
dc.identifier.doi10.3390/molecules28207152pt_PT
dc.identifier.issn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.8/8971
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationNovel Chemical Stratefies for early detection of neurodegenerative diseases
dc.relation.publisherversionhttps://www.mdpi.com/1420-3049/28/20/7152pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMagnetic organic saltspt_PT
dc.subjectTerbium saltspt_PT
dc.subjectGadolinium saltspt_PT
dc.subjectMRI contrast agentspt_PT
dc.subjectCytotoxicitypt_PT
dc.titleLanthanide-based organic salts: Synthesis, characterization, and cytotoxicity studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNovel Chemical Stratefies for early detection of neurodegenerative diseases
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/PD%2FBD%2F109625%2F2015/PT
oaire.citation.issue20pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume28pt_PT
oaire.fundingStreamOE
person.familyNameForte
person.familyNameGago
person.familyNameAlves
person.familyNameSilva
person.familyNamePedrosa
person.familyNameLaia
person.familyNameMarrucho
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person.givenNameAndreia
person.givenNameSandra
person.givenNameCelso
person.givenNameJoana
person.givenNameRui
person.givenNameCésar
person.givenNameIsabel
person.givenNameLuis
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person.identifier.orcid0000-0003-2520-1151
person.identifier.ridL-2025-2014
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
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