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Electrospun polycaprolactone (PCL) degradation: An in vitro and in vivo study

2022Journal article Open access
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dc.contributor.authorDias, Juliana R.
dc.contributor.authorSousa, Aureliana
dc.contributor.authorAugusto, Ana
dc.contributor.authorBártolo, Paulo J.
dc.contributor.authorGranja, Pedro L.
dc.date.accessioned2023-08-23T10:32:11Z
dc.date.available2023-08-23T10:32:11Z
dc.date.issued2022
dc.descriptionThis work was supported by the Fundação para a Ciência e a Tecnologia (FCT) through the following projects: CDRSP: UIDB/04044/2020, UIDP/04044/2020 and MARE: UIDB/04292/2020 and UIDP/04292/2020. This study was also supported by PAMI-ROTEIRO/0328/2013 (No. 022158), MATIS (CENTRO-01-0145-FEDER-000014-3362), SpinningTNT (POCI-01-02B7-FEDER-069285), and the project LA/P/0069/2020 granted to the Associate Laboratory ARNET.pt_PT
dc.description.abstractPolycaprolactone (PCL) is widely used in tissue engineering due to its interesting properties, namely biocompatibility, biodegradability, elastic nature, availability, cost efficacy, and the approval of health authorities such as the American Food and Drug Administration (FDA). The PCL degradation rate is not the most adequate for specific applications such as skin regeneration due to the hydrophobic nature of bulk PCL. However, PCL electrospun fiber meshes, due to their low diameters resulting in high surface area, are expected to exhibit a fast degradation rate. In this work, in vitro and in vivo degradation studies were performed over 90 days to evaluate the potential of electrospun PCL as a wound dressing. Enzymatic and hydrolytic degradation studies in vitro, performed in a static medium, demonstrated the influence of lipase, which promoted a rate of degradation of 97% for PCL meshes. In an in vivo scenario, the degradation was slower, although the samples were not rejected, and were well-integrated in the surrounding tissues inside the subcutaneous pockets specifically created.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDias, J.R.; Sousa, A.; Augusto, A.; Bártolo, P.J.; Granja, P.L. Electrospun Polycaprolactone (PCL) Degradation: An In Vitro and In Vivo Study. Polymers 2022, 14, 3397. https://doi.org/10.3390/ polym14163397pt_PT
dc.identifier.doi10.3390/polym14163397pt_PT
dc.identifier.issn2073-4360
dc.identifier.urihttp://hdl.handle.net/10400.8/8724
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationMarine and Environmental Sciences Centre
dc.relation.publisherversionhttps://www.mdpi.com/2073-4360/14/16/3397pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolycaprolactonept_PT
dc.subjectEletrospinning nanofiberspt_PT
dc.subjectDegradationpt_PT
dc.subjectEnzymaticpt_PT
dc.titleElectrospun polycaprolactone (PCL) degradation: An in vitro and in vivo studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.citation.issue16pt_PT
oaire.citation.titlePolymerspt_PT
oaire.citation.volume14pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameDias
person.familyNamede Castro e Sousa
person.familyNameSousa Augusto
person.familyNameBartolo
person.familyNameGranja
person.givenNameJuliana
person.givenNameAureliana Filipa
person.givenNameAna Luísa de
person.givenNamePaulo
person.givenNamePedro
person.identifier633669
person.identifierG-6286-2014
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person.identifier.ciencia-id5810-9BF9-4522
person.identifier.ciencia-idDB1F-B9B7-E4FD
person.identifier.orcid0000-0002-7079-1069
person.identifier.orcid0000-0003-2191-8892
person.identifier.orcid0000-0001-8561-6848
person.identifier.orcid0000-0003-3683-726X
person.identifier.orcid0000-0003-2761-4929
person.identifier.ridA-6086-2014
person.identifier.ridF-2421-2013
person.identifier.ridB-1685-2008
person.identifier.scopus-author-id55749822200
person.identifier.scopus-author-id35345790700
person.identifier.scopus-author-id6603353041
person.identifier.scopus-author-id6602391346
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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