Biofabrication for osteochondral tissue regeneration: bioink printability requirements

Abdulghani, Saba; Morouço, Pedro G.

http://hdl.handle.net/10400.8/8482

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Authors

Abdulghani, Saba

Morouço, Pedro G.

Abstract(s)

Biofabrication allows the formation of 3D scaffolds through a precise spatial control. This is of foremost importance when aiming to mimic heterogeneous and anisotropic architecture, such as that of the osteochondral tissue. Osteochondral defects are a supreme challenge for tissue engineering due to the compositional and structural complexity of stratified architecture and contrasting biomechanical properties of the cartilage-bone interface. This review highlights the advancements and retreats witnessed by using developed bioinks for tissue regeneration, taking osteochondral tissue as a challenging example. Methods, materials and requirements for bioprinting were discussed, highlighting the pre and post-processing factors that researchers should consider towards the development of a clinical treatment.

Description

This work was funded by PAMI (ROTEIRO/0328/2013; Nº 022158), a Research Infrastructure of the National Roadmap of Research Infrastructures of Strategic Relevance for 2014–2020, co-funded by the FCT and European Union through the Centro2020.

URI

http://hdl.handle.net/10400.8/8482

Citation

Abdulghani, S., Morouço, P.G. Biofabrication for osteochondral tissue regeneration: bioink printability requirements. J Mater Sci: Mater Med 30, 20 (2019). https://doi.org/10.1007/s10856-019-6218-x