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Effects of Hormonal Replacement Therapy and Mindfulness-Based Stress Reduction on Climacteric Symptoms Following Risk-Reducing Salpingo-Oophorectomy

2024-08-13Journal article Open access
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dc.contributor.authorAli, Amira Mohammed
dc.contributor.authorAl-Dossary, Saeed A.
dc.contributor.authorLaranjeira, Carlos
dc.contributor.authorAmer, Faten
dc.contributor.authorHallit, Souheil
dc.contributor.authorAlkhamees, Abdulmajeed A.
dc.contributor.authorAljubilah, Aljawharah Fahad
dc.contributor.authorAljaberi, Musheer A.
dc.contributor.authorAlzeiby, Ebtesam Abdullah
dc.contributor.authorFadlalmola, Hammad Ali
dc.contributor.authorPakai, Annamaria
dc.contributor.authorKhatatbeh, Haitham
dc.date.accessioned2024-09-10T18:48:35Z
dc.date.available2024-09-10T18:48:35Z
dc.date.issued2024-08-13
dc.descriptionThis article belongs to the Special Issue Mental Health Promotion and Illness Prevention in Vulnerable Populations—2nd Edition.pt_PT
dc.descriptionSupplementary Materials The following supporting information can be downloaded at https://www.mdpi.com/article/10.3390/healthcare12161612/s1: Supplementary Table S1: Fit indices of multi-group analysis models examining the differences in the effects of mindfulness-based stress reduction (MBSR) and hormone replacement therapy (HRT) among women with RRSO, File S2: Possible mechanism of menopausal symptom flaring following HRT treatment in RRSO patients with BRCA1 mutation and a history of cancer.pt_PT
dc.descriptionFunding: This work was supported by FCT—Fundação para a Ciência e a Tecnologia, I.P. (UIDB/05704/2020 and UIDP/05704/2020) and by the Scientific Employment Stimulus—Institutional Call [https://doi.org/10.54499/CEECINST/00051/2018/CP1566/CT0012, accessed on 30 July 2024].pt_PT
dc.description.abstractBreast Cancer Associated Susceptibility Proteins Type 1/2 (BRCA1/2) promote cellular functioning by modulating NRF2-mediated antioxidant signaling. Redox failure in women with BRCA1/2 insufficiency increases the risk for breast/ovarian/uterine cancers. Risk-reducing salpingo-oophorectomy (RRSO) is a prophylactic surgery of the reproductive organs, which is frequently conducted by the age of 40 to lower the occurrence of cancer in women with BRCA1/2 mutations. However, abrupt estrogen decline following RRSO causes ovarian failure, which implicates various cellular physiological processes, resulting in the increased release of free radicals and subsequent severe onset of menopausal symptoms. Comfort measures (e.g., hormonal replacement therapy (HRT) and mindfulness-based stress reduction (MBSR)) may improve chronological menopause-related quality of life, but their specific effects are not clear in women with gene mutations. Aiming to fill the gap, this study used path analysis to examine the effects of HRT and MBSR on menopausal symptoms among RRSO patients (N = 199, mean age = 50.5 ± 6.7 years). HRT directly alleviated the levels of urogenital symptoms (β = −0.195, p = 0.005), which mediated its indirect significant effects on the somatic–vegetative and psychological symptoms of menopause (β = −0.046, −0.067; both p values = 0.004, respectively), especially in BRCA2 carriers and in women who were currently physically active, premenopausal at the time of RRSO, had a high BMI, and had no history of breast cancer. It increased the severity of urogenital symptoms in women with a history of cancer. MBSR, on the other hand, was associated with indirect increases in the intensity of the somatic–vegetative and psychological symptoms of menopause (β = 0.108, 0.029; p = 0.003, 0.033, respectively). It exerted positive direct effects on different menopausal symptoms in multigroup analysis. The results suggest that young women undergoing recent RRSO may benefit from HRT at an individual level, while their need for extensive measures to optimize their psychological wellbeing is ongoing. The adverse effects of MBSR, which are captured in the present study, imply that MBSR may interfere with redox sensitivity associated with estradiol fluctuations in BRCA1/2 carriers. Investigations are needed to test this hypothesis and elaborate on the underlying mechanisms in these women.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAli, A.M.; Al-Dossary, S.A.; Laranjeira, C.; Amer, F.; Hallit, S.; Alkhamees, A.A.; Aljubilah, A.F.; Aljaberi, M.A.; Alzeiby, E.A.; Fadlalmola, H.A.; et al. Effects of Hormonal Replacement Therapy and Mindfulness-Based Stress Reduction on Climacteric Symptoms Following Risk-Reducing Salpingo-Oophorectomy. Healthcare 2024, 12, 1612. https:// doi.org/10.3390/healthcare12161612pt_PT
dc.identifier.doihttps://doi.org/10.3390/healthcare12161612pt_PT
dc.identifier.eissn2227-9032
dc.identifier.urihttp://hdl.handle.net/10400.8/10036
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPI (Multidisciplinary Digital Publishing Institute)pt_PT
dc.relationCenter for Innovative Care and Health Technology
dc.relationCenter for Innovative Care and Health Technology
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/2227-9032/12/16/1612pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHormonal replacement therapy (HRT)pt_PT
dc.subjectMindfulness-based stress reduction (MBSR)pt_PT
dc.subjectRisk-reducing salpingo-oophorectomy (RRSO)pt_PT
dc.subjectBreast Cancer Associated Susceptibility Protein Type 1/2 (BRCA1/2) mutationspt_PT
dc.subjectMenopause rating scale (MRS)pt_PT
dc.subjectMenopause/perimenopause/postmenopausalpt_PT
dc.subjectPsychological symptomspt_PT
dc.subjectPhysical activity/exercisept_PT
dc.subjectBreast cancerpt_PT
dc.titleEffects of Hormonal Replacement Therapy and Mindfulness-Based Stress Reduction on Climacteric Symptoms Following Risk-Reducing Salpingo-Oophorectomypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F05704%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00051%2F2018%2FCP1566%2FCT0012/PT
oaire.citation.issue16pt_PT
oaire.citation.startPage1612pt_PT
oaire.citation.titleHealthcarept_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC INST 2018
person.familyNameLaranjeira
person.givenNameCarlos
person.identifier.orcid0000-0003-1080-9535
person.identifier.scopus-author-id22957802900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication7c2157d8-cac9-4004-9438-e92fec260842
relation.isAuthorOfPublication.latestForDiscovery7c2157d8-cac9-4004-9438-e92fec260842
relation.isProjectOfPublicationd421b07d-3471-4026-aa43-def80b8e142b
relation.isProjectOfPublicatione5ceb42e-60fb-425d-8576-b213fc64081f
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