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Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida

2019Journal article Restricted access
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dc.contributor.authorSilva, J. Paulo
dc.contributor.authorAlves, Celso
dc.contributor.authorPinteus, Susete
dc.contributor.authorSilva, Joana
dc.contributor.authorValado, Ana
dc.contributor.authorPedrosa, Rui
dc.contributor.authorPereira, Leonel
dc.date.accessioned2020-08-12T10:51:06Z
dc.date.available2020-08-12T10:51:06Z
dc.date.issued2019
dc.descriptionThis work had the support of Fundação para a Ciência e Tecnologia (FCT), through the strategic project (No. UID/MAR/04292/2013) granted to MARE. This work had also the support from the European Union through EASME Blue Labs project AMALIA—Algae-to-MArket Lab IdeAs (No.EASME/EMFF/2016/1.2.1.4/03/SI2.750419). Received funding from European Structural & Investment Funds through the COMPETE Programme and from National Funds through FCT—Fundação para a Ciência e a Tecnologia under the Programme (No.SAICTPAC/0019/2015).pt_PT
dc.description.abstractOsmundea pinnatifida is a red edible seaweed known as pepper dulse. O. pinnatifida was cultivated in the farm of ALGAplus (Ílhavo, Portugal). This farm is integrated with a seabream and seabass commercial aquaculture and uses the nutrient-enriched water resultant from the fish production as its cultivation medium in the integrated multi-trophic aquaculture (IMTA) manner. Wild and IMTA-cultivated samples of O. pinnatifida were screened for antioxidant and antitumor activities. The antioxidant capacity of solvent extracts from wild and IMTA cultivated samples was assessed in two methods (2,2-diphenyl- 1-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC)), and their total phenolic contents (TPC) were estimated. Antitumor activity was evaluated in three different tumor cell lines (HepG- 2, MCF-7, and SH-SY5Y) through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Among the solvents used for extraction, dichloromethane was the most effective to extract phenolic compounds and presented higher ORAC. A significant correlation was found between TPC and ORAC, which was also sustained by the principal components analysis (PCA). Dichloromethane extracts induced a cytostatic effect on MCF-7 cells and showed weak cytotoxicity to SH-SY5Y cells and weak impact on cell proliferation. Overall, there were no statistically signifi cant diff erences in the biological activities shown by the wild and IMTA-cultivated samples. Hence, O. pinnatifida can be obtained in an economical and environmentally sustainable way through IMTA, maintaining bioactive properties in a high potential for further nutraceutical purposes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, P.J. & Alves, C. & Pinteus, S. & Silva, J. & Valado, A. & Pedrosa, R. & Pereira, L. (2019). Antioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifida. Journal of Oceanology and Limnology. 37. 825-835. 10.1007/s00343-019-8110-4.pt_PT
dc.identifier.doi10.1007/s00343-019-8110-4pt_PT
dc.identifier.issn1993-5005
dc.identifier.urihttp://hdl.handle.net/10400.8/5070
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.relationPRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectEdible seaweedpt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectPolyphenolspt_PT
dc.subjectCytotoxic activitypt_PT
dc.subjectAntiproliferative activitypt_PT
dc.titleAntioxidant and antitumor potential of wild and IMTA-cultivated Osmundea pinnatifidapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMAR%2F04292%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/SAICTPAC%2F0019%2F2015/PT
oaire.citation.endPage835pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage825pt_PT
oaire.citation.titleChinese Journal of Oceanology and Limnologypt_PT
oaire.citation.volume37pt_PT
oaire.fundingStream5876
oaire.fundingStream9471 - RIDTI
person.familyNameAlves
person.familyNamePinteus
person.familyNameSilva
person.familyNamePedrosa
person.givenNameCelso
person.givenNameSusete
person.givenNameJoana
person.givenNameRui
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person.identifier.scopus-author-id55654969100
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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