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Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases

2014-05-20Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg07:Energias Renováveis e Acessíveis
datacite.subject.sdg11:Cidades e Comunidades Sustentáveis
dc.contributor.authorCrozet, Pierre
dc.contributor.authorMargalha, Leonor
dc.contributor.authorConfraria, Ana
dc.contributor.authorRodrigues, Américo
dc.contributor.authorMartinho, Cláudia
dc.contributor.authorAdamo, Mattia
dc.contributor.authorElias, Carlos A.
dc.contributor.authorBaena-Gonzalez, Elena
dc.date.accessioned2026-06-09T10:41:52Z
dc.date.available2026-06-09T10:41:52Z
dc.date.issued2014-05-20
dc.description.abstractTheSNF1(sucrosenon-fermenting1)-relatedproteinkinases1(SnRKs1)aretheplantorthologsofthebuddingyeastSNF1andmammalianAMPK(AMP- activatedproteinkinase).Theseevolutionarilyconservedkinasesaremetabolicsensorsthatundergoactivationinresponsetodecliningenergylevels.Uponactivation,SNF1/AMPK/SnRK1kinasestriggeravasttranscriptionalandmetabolicreprogramingthatrestoresenergyhomeostasisandpromotestolerancetoadverseconditions,partlythroughaninductionofcatabolicprocessesandageneralrepressionofanabolism.Thesekinasestypicallyfunctionasaheterotrimericcomplexcomposedoftworegulatorysubunits,βandγ,andanα-catalyticsubunit,whichrequiresphosphorylationofaconservedactivationloopresidueforactivity.Additionally,SNF1/AMPK/SnRK1kinasesarecontrolledbymultiplemechanismsthathaveanimpactonkinaseactivity,stability,and/orsubcellularlocalization.HerewewillreviewcurrentknowledgeontheregulationofSNF1/AMPK/SnRK1byupstreamcomponents,post-translationalmodifications,variousmetabolites,hormones,andothers,inanattempttohighlightboththecommonalitiesoftheseessentialeukaryotickinasesandthedivergencesthathaveevolvedtocopewiththeparticularitiesofeachoneofthesesystems.eng
dc.description.sponsorshipPierreCrozet,AnaConfraria,LeonorMargalha,andCláudiaMartinhoweresupportedbyFundaçãoparaaCiênciaeTecnolo- giafellowships(SFRH/BPD/79255/2011,SFRH/BPD/47280/2008, SFRH/BD/51627/2011, andSFRH/BD/33563/2008,respectively). The ElenaBaena-Gonzálezlabissupportedbygrantsfromthe EMBOInstallationProgram,MarieCurieActionsFP7-People- 2010-ITN (MERIT),andFundaçãoparaaCiência e a Tecnologia (PTDC/BIA-PLA/3937/2012).
dc.identifier.citationRodrigues, A., Adamo, M., Margalha, L., Baena-González, E., Crozet, P., Confraria, A., Elias, C. A., & Martinho, C. (2014). Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Frontiers in Plant Science, 5, 190. https://doi.org/10.3389/fpls.2014.00190
dc.identifier.doi10.3389/fpls.2014.00190
dc.identifier.issn1664-462X
dc.identifier.urihttp://hdl.handle.net/10400.8/16389
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media SA
dc.relation.hasversionhttps://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2014.00190/full
dc.relation.ispartofFrontiers in Plant Science
dc.rights.uriN/A
dc.subjectSnRK1
dc.subjectSNF1
dc.subjectAMPK
dc.subjectStress
dc.subjectEnergy signaling
dc.subjectArabidopsis
dc.subjectKinase regulation
dc.titleMechanisms of regulation of SNF1/AMPK/SnRK1 protein kinaseseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Plant Science
oaire.citation.volume5
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameRodrigues
person.givenNameAmérico
person.identifier.orcid0000-0002-5293-5583
person.identifier.ridF-9573-2010
person.identifier.scopus-author-id15745701600
relation.isAuthorOfPublication718ad6e8-1d3a-4ce3-9870-e4ed6732c30b
relation.isAuthorOfPublication.latestForDiscovery718ad6e8-1d3a-4ce3-9870-e4ed6732c30b

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