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Orientador(es)
Resumo(s)
TheSNF1(sucrosenon-fermenting1)-relatedproteinkinases1(SnRKs1)aretheplantorthologsofthebuddingyeastSNF1andmammalianAMPK(AMP- activatedproteinkinase).Theseevolutionarilyconservedkinasesaremetabolicsensorsthatundergoactivationinresponsetodecliningenergylevels.Uponactivation,SNF1/AMPK/SnRK1kinasestriggeravasttranscriptionalandmetabolicreprogramingthatrestoresenergyhomeostasisandpromotestolerancetoadverseconditions,partlythroughaninductionofcatabolicprocessesandageneralrepressionofanabolism.Thesekinasestypicallyfunctionasaheterotrimericcomplexcomposedoftworegulatorysubunits,βandγ,andanα-catalyticsubunit,whichrequiresphosphorylationofaconservedactivationloopresidueforactivity.Additionally,SNF1/AMPK/SnRK1kinasesarecontrolledbymultiplemechanismsthathaveanimpactonkinaseactivity,stability,and/orsubcellularlocalization.HerewewillreviewcurrentknowledgeontheregulationofSNF1/AMPK/SnRK1byupstreamcomponents,post-translationalmodifications,variousmetabolites,hormones,andothers,inanattempttohighlightboththecommonalitiesoftheseessentialeukaryotickinasesandthedivergencesthathaveevolvedtocopewiththeparticularitiesofeachoneofthesesystems.
Descrição
Palavras-chave
SnRK1 SNF1 AMPK Stress Energy signaling Arabidopsis Kinase regulation
Contexto Educativo
Citação
Rodrigues, A., Adamo, M., Margalha, L., Baena-González, E., Crozet, P., Confraria, A., Elias, C. A., & Martinho, C. (2014). Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases. Frontiers in Plant Science, 5, 190. https://doi.org/10.3389/fpls.2014.00190
Editora
Frontiers Media SA
Licença CC
Sem licença CC