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Discriminative influence of persistent organic pollutants on nesting green sea turtles through genotoxicity, oxidative stress and reproductive related markers

2025-09Journal article Open access
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datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorMorão, Inês
dc.contributor.authorMuñoz-Arnanz, Juan
dc.contributor.authorSimões, Tiago
dc.contributor.authorBartalini, Alice
dc.contributor.authorVieira, Sara
dc.contributor.authorFerreira-Airaud, Betânia
dc.contributor.authorCaliani, Ilaria
dc.contributor.authorNoi, Agata Di
dc.contributor.authorCasini, Silvia
dc.contributor.authorFossi, Maria Cristina
dc.contributor.authorJiménez, Begoña
dc.contributor.authorLemos, Marco
dc.contributor.authorNovais, Sara
dc.date.accessioned2025-09-15T14:30:33Z
dc.date.available2025-09-15T14:30:33Z
dc.date.issued2025-09
dc.description.abstractPersistent organic pollutants (POPs) including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochloride pesticides (OCPs) affect biodiversity by bioaccumulating through food webs, impacting marine organisms like endangered sea turtles. This study represents the first evaluation of these contaminants in sea turtles nesting in São Tomé and Príncipe. The main goal was to evaluate PCBs, PBDEs and OCPs levels in sea turtles' blood and investigate their potential effects on erythrocytes’ nuclear abnormalities (ENAs) and oxidative stress and reproduction-related gene expression. The relative mean abundance for contaminants was ΣPCBs > ΣOCPs > ΣPBDEs. Contaminants such as PCB-28, PCB-138, PCB-153, PCB-180 and p,p’-DDE were associated with ENAs, suggesting potential genetic instability and cellular disruption. PCB-126, PBDE-100, and o,p’-DDD correlated with antioxidant and detoxification genes (glrx3, gst, txnip, txnrd2, and gclc), suggesting oxidative stress responses. The reproduction-related gene est17 was correlated with α and β-HCH, potentially affecting ovary development. Correlations between ace2 and various PCBs, PBDEs, and o,p'-DDD suggest disruptions in follicular development and egg transport. Embryo development genes (hoxA1 and tuba1) were associated with PBDE-154, PBDE100 and o,p’-DDD, suggesting possible embryonic alterations. These findings highlight the impacts of POPs on nesting female green turtles in São Tomé, threatening this endangered population.eng
dc.description.sponsorshipThis study was supported by the Fundação para a Ciência e a Tecnologia (FCT) through the Strategic Project granted to MARE (UID/04292/MARE-Centro de Ciências do Mar e do Ambiente), the project granted to the Associated Laboratory ARNET (doi.org/10.54499/LA/P/0069/2020), the grant awarded to Inês Morão (https://doi.org/10.54499/PD/BD/150562/2019), and contracts to Tiago Simões (https://doi.org/10.54499/2021.02559.CEECIND/CP1671/CT0001) and Sara Novais (https://doi.org/10.54499/CEECINST/00060/2021/CP2902/CT0007). We are thankful to all the members of NGO Programa Tatô, Fundação Príncipe and research assistants (marine biologists Maria Branco and Yedda Oliveira) working at Jalé Beach and to Aurélio Evaristo and João Evaristo that helped us in the field under challenging conditions.
dc.identifier.citationInês F.C. Morão, Juan Muñoz-Arnanz, Tiago Simões, Alice Bartalini, Sara Vieira, Betânia Ferreira-Airaud, Ilaria Caliani, Agata Di Noi, Silvia Casini, Maria Cristina Fossi, Begoña Jiménez, Marco F.L. Lemos, Sara C. Novais, Discriminative influence of persistent organic pollutants on nesting green sea turtles through genotoxicity, oxidative stress and reproductive related markers, Journal of Hazardous Materials, 2025, 139762, ISSN 0304-3894, https://doi.org/10.1016/j.jhazmat.2025.139762.
dc.identifier.doi10.1016/j.jhazmat.2025.139762
dc.identifier.issn0304-3894
dc.identifier.urihttp://hdl.handle.net/10400.8/14064
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationAquatic Research Infrastructure Network
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0304389425026810?via%3Dihub
dc.relation.ispartofJournal of Hazardous Materials
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectPCBs
dc.subjectPBDEs
dc.subjectOCPs
dc.subjectTEQ values
dc.subjectOxidative stress
dc.subjectReproduction
dc.titleDiscriminative influence of persistent organic pollutants on nesting green sea turtles through genotoxicity, oxidative stress and reproductive related markerseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAR%2F04292%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0069%2F2020/PT
oaire.citation.titleJournal of Hazardous Materials
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_fa2ee174bc00049f
person.familyNameMorão
person.familyNameLemos
person.familyNameNovais
person.givenNameInês
person.givenNameMarco
person.givenNameSara
person.identifier996337
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person.identifier.ciencia-id971F-ACCA-C0D1
person.identifier.ciencia-id2216-A2E0-A118
person.identifier.orcid0000-0001-7329-2196
person.identifier.orcid0000-0001-9887-1864
person.identifier.orcid0000-0003-1306-3396
person.identifier.ridF-7951-2011
person.identifier.ridA-9032-2012
person.identifier.scopus-author-id7006042884
person.identifier.scopus-author-id23025463300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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