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Unravelling the dermatological potential of the brown seaweed Carpomitra costata

2021Journal article Open access
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dc.contributor.authorSusano, Patrícia
dc.contributor.authorSilva, Joana
dc.contributor.authorAlves, Celso
dc.contributor.authorMartins, Alice
dc.contributor.authorGaspar, Helena
dc.contributor.authorPinteus, Susete
dc.contributor.authorMouga, Teresa
dc.contributor.authorGoettert, Márcia Ines
dc.contributor.authorPetrovski, Zeljko
dc.contributor.authorBranco, Luís B.
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2021-08-03T12:13:46Z
dc.date.available2021-08-03T12:13:46Z
dc.date.issued2021
dc.descriptionThis work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic projects UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre, UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, and FCT/MCTES (UIDB/50006/2020) granted to the Associate Laboratory for Green Chemistry-LAQV. The authors are also very grateful to financial support attained through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01-0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIAOUT/29250/2017), co-financed by COMPETE (POCI-01-0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017).
dc.description.abstractThe ever-increasing interest in keeping a young appearance and healthy skin has leveraged the skincare industry. This, coupled together with the increased concern regarding the safety of synthetic products, has boosted the demand for new and safer natural ingredients. Accordingly, the aim of this study was to evaluate the dermatological potential of the brown seaweed Carpomitra costata. The antioxidant, anti-enzymatic, antimicrobial, photoprotective and anti-inflammatory properties of five C. costata fractions (F1–F5) were evaluated. The ethyl acetate fraction (F3) demonstrated the most promising results, with the best ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (EC50 of 140.1 g/mL) and the capacity to reduce reactive oxygen species (ROS) production promoted by UVA and UVB radiation in 3T3 cells, revealing its antioxidant and photoprotective potential. This fraction also exhibited the highest anti-enzymatic capacity, inhibiting the activities of collagenase, elastase and tyrosinase (IC50 of 7.2, 4.8 and 85.9 g/mL, respectively). Moreover, F3 showed anti-inflammatory potential, reducing TNF- and IL-6 release induced by LPS treatment in RAW 264.7 cells. These bioactivities may be related to the presence of phenolic compounds, such as phlorotannins, as demonstrated by NMR analysis. The results highlight the potential of C. costata as a source of bioactive ingredients for further dermatological applications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSusano, P.; Silva, J.; Alves, C.; Martins, A.; Gaspar, H.; Pinteus, S.; Mouga, T.; Goettert, M.I.; Petrovski, Ž.; Branco, L.B.; et al. Unravelling the Dermatological Potential of the Brown Seaweed Carpomitra costata. Mar. Drugs 2021, 19, 135. https://doi.org/10.3390/md19030135pt_PT
dc.identifier.doi10.3390/md19030135pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.8/5993
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationBiosystems and Integrative Sciences Institute
dc.relationBiosystems and Integrative Sciences Institute
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.publisherversionhttps://www.mdpi.com/1660-3397/19/3/135/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlgaept_PT
dc.subjectAnti-enzymaticpt_PT
dc.subjectAnti-inflammatorypt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectAntioxidantpt_PT
dc.subjectMarine natural productspt_PT
dc.subjectPhenolic compoundspt_PT
dc.subjectPhotoprotectivept_PT
dc.subjectSkincarept_PT
dc.titleUnravelling the dermatological potential of the brown seaweed Carpomitra costatapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04046%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-BQM%2F28355%2F2017/PT
oaire.citation.titleMarine drugspt_PT
oaire.citation.volume19pt_PT
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person.familyNameFrederico Susano
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