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Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide

2014-11Artigo científico Acesso restrito
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datacite.subject.fosCiências Médicas::Outras Ciências Médicas
datacite.subject.fosCiências Naturais::Ciências da Terra e do Ambiente
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosCiências Naturais::Ciências Químicas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
datacite.subject.sdg13:Ação Climática
datacite.subject.sdg14:Proteger a Vida Marinha
dc.contributor.authorLarguinho, Miguel
dc.contributor.authorCordeiro, Ana
dc.contributor.authorDiniz, Mário S.
dc.contributor.authorCosta, Pedro M.
dc.contributor.authorBaptista, Pedro V.
dc.date.accessioned2026-07-03T14:54:49Z
dc.date.available2026-07-03T14:54:49Z
dc.date.issued2014-11
dc.description.abstractAlthough the neurotoxic and genotoxic potential of acrylamide has been established in freshwater fish, the full breadth of the toxicological consequences induced by this xenobiotic has not yet been disclosed, particularly in aquatic invertebrates. To assess the effects of acrylamide on a bivalve model, the Mediterranean mussel (Mytilus galloprovincialis), two different setups were accomplished: 1) acute exposure to several concentrations of waterborne acrylamide to determine lethality thresholds of the substance and 2) chronic exposure to more reduced acrylamide concentrations to survey phases I and II metabolic endpoints and to perform a whole-body screening for histopathological alterations. Acute toxicity was low (LC50≈400mg/L). However, mussels were responsive to prolonged exposure to chronic concentrations of waterborne acrylamide (1-10mg/L), yielding a significant increase in lipid peroxidation plus EROD and GST activities. Still, total anti-oxidant capacity was not exceeded. In addition, no neurotoxic effects could be determined through acetylcholine esterase (AChE) activity. The findings suggest aryl-hydrocarbon receptor (Ahr)-dependent responses in mussels exposed to acrylamide, although reduced comparatively to vertebrates. No significant histological damage was found in digestive gland or gills but female gonads endured severe necrosis and oocyte atresia. Altogether, the results indicate that acrylamide may induce gonadotoxicity in mussels, although the subject should benefit from further research. Altogether, the findings suggest that the risk of acrylamide to aquatic animals, especially molluscs, may be underestimated.eng
dc.description.sponsorshipThe authors acknowledge the Portuguese ‘Fundação para a Ciência e Tecnologia’ (FCT/MEC) for funding: CIGMH (PEst-OE/SAU/UI0009/2011-14); REQUIMTE (PEst-C/EQB/LA0006/2011); IMAR (PEst-C/MAR/UI0284/2011); the research project Ref. PTDC/BBB-NAN/1812/2012; plus the Grants SFRH/BD/64026/2009 for M. Larguinho and SFRH/BPD/72564/2010 for P.M. Costa.
dc.identifier.citationMiguel Larguinho, Ana Cordeiro, Mário S. Diniz, Pedro M. Costa, Pedro V. Baptista, Metabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamide, Environmental Research, Volume 135, 2014, Pages 55-62, ISSN 0013-9351, https://doi.org/10.1016/j.envres.2014.09.004.
dc.identifier.doi10.1016/j.envres.2014.09.004
dc.identifier.eissn1096-0953
dc.identifier.issn0013-9351
dc.identifier.urihttp://hdl.handle.net/10400.8/16537
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationSilence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy
dc.relationANALYSIS OF THE GENOTOXIC POTENTIAL OF ESTUARINE SEDIMENTS AND THE DNA REPAIR AND APOPTOSIS-RELATED RESPONSES IN HUMAN HEPG2 CELLS
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S0013935114003077?via%3Dihub
dc.relation.ispartofEnvironmental Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAcrylamide
dc.subjectMussels
dc.subjectChronic exposure
dc.subjectOxidative stress
dc.subjectReproductive toxicity
dc.subjectHistopathology
dc.titleMetabolic and histopathological alterations in the marine bivalve Mytilus galloprovincialis induced by chronic exposure to acrylamideeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/BBB-NAN/1812/2012
oaire.awardNumberSFRH/BPD/72564/2010
oaire.awardTitleSilence is golden (siAu) - silencing the silencers via multifunctional gold nanoconjugates towards cancer therapy
oaire.awardTitleANALYSIS OF THE GENOTOXIC POTENTIAL OF ESTUARINE SEDIMENTS AND THE DNA REPAIR AND APOPTOSIS-RELATED RESPONSES IN HUMAN HEPG2 CELLS
oaire.awardURIhttp://hdl.handle.net/10400.8/13252
oaire.awardURIhttp://hdl.handle.net/10400.8/16536
oaire.citation.endPage62
oaire.citation.startPage55
oaire.citation.titleEnvironmental Research
oaire.citation.volume135
oaire.fundingStream3599-PPCDT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCosta
person.givenNamePedro M.
person.identifier.orcid0000-0002-9072-3522
relation.isAuthorOfPublication01d7c7c5-8ff1-48c8-a0ca-576b1e89a02c
relation.isAuthorOfPublication.latestForDiscovery01d7c7c5-8ff1-48c8-a0ca-576b1e89a02c
relation.isProjectOfPublication58470b3e-1573-4d09-ba58-4692f2e1fee7
relation.isProjectOfPublication94e4b0a6-ce4a-42af-8b23-8fa74b2aabfc
relation.isProjectOfPublication.latestForDiscovery58470b3e-1573-4d09-ba58-4692f2e1fee7

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Although the neurotoxic and genotoxic potential of acrylamide has been established in freshwater fish, the full breadth of the toxicological consequences induced by this xenobiotic has not yet been disclosed, particularly in aquatic invertebrates. To assess the effects of acrylamide on a bivalve model, the Mediterranean mussel (Mytilus galloprovincialis), two different setups were accomplished: 1) acute exposure to several concentrations of waterborne acrylamide to determine lethality thresholds of the substance and 2) chronic exposure to more reduced acrylamide concentrations to survey phases I and II metabolic endpoints and to perform a whole-body screening for histopathological alterations. Acute toxicity was low (LC50≈400mg/L). However, mussels were responsive to prolonged exposure to chronic concentrations of waterborne acrylamide (1-10mg/L), yielding a significant increase in lipid peroxidation plus EROD and GST activities. Still, total anti-oxidant capacity was not exceeded. In addition, no neurotoxic effects could be determined through acetylcholine esterase (AChE) activity. The findings suggest aryl-hydrocarbon receptor (Ahr)-dependent responses in mussels exposed to acrylamide, although reduced comparatively to vertebrates. No significant histological damage was found in digestive gland or gills but female gonads endured severe necrosis and oocyte atresia. Altogether, the results indicate that acrylamide may induce gonadotoxicity in mussels, although the subject should benefit from further research. Altogether, the findings suggest that the risk of acrylamide to aquatic animals, especially molluscs, may be underestimated.
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