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Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles

2021Journal article Open access
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dc.contributor.authorJuan Mora, Blanca de
dc.contributor.authorFilipe, Luís
dc.contributor.authorForte, Andreia
dc.contributor.authorSantos, Miguel M.
dc.contributor.authorAlves, Celso
dc.contributor.authorTeodoro, Fernando
dc.contributor.authorPedrosa, Rui
dc.contributor.authorCarrott, Manuela Ribeiro
dc.contributor.authorBranco, Luís C.
dc.contributor.authorGago, Sandra
dc.date.accessioned2021-08-03T12:03:14Z
dc.date.available2021-08-03T12:03:14Z
dc.date.issued2021
dc.descriptionThe authors also thank Fundação para a Ciência e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as MAR2020 (MAR-02.01.01-FEAMP-0042–INOVA4AQUA). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). This work was supported by the Associate Laboratory for Green Chemistry LAQV and MARE—Marine and Environmental Sciences Centre which are financed by national funds from FCT/MCTES (UIDB/50006/2020 and UID/MAR/04292/2020, respectively)
dc.description.abstractMesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution 1H NMR spectroscopies, elemental analysis, XRD and N2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanom aterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationde Juan Mora, B.; Filipe, L.; Forte, A.; Santos, M.M.; Alves, C.; Teodoro, F.; Pedrosa, R.; Ribeiro Carrott, M.; Branco, L.C.; Gago, S. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics 2021, 13, 218. https:// doi.org/10.3390/pharmaceutics13020218pt_PT
dc.identifier.doi10.3390/pharmaceutics13020218pt_PT
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10400.8/5992
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/13/2/218/htmpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCiprofloxacinpt_PT
dc.subjectIonic liquidspt_PT
dc.subjectMesoporous silica nanoparticlespt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectAntimicrobial activitypt_PT
dc.titleBoosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticlespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameSantos
person.familyNameAlves
person.familyNameTeodoro
person.familyNamePedrosa
person.familyNameGago
person.givenNameMiguel
person.givenNameCelso
person.givenNameFernando
person.givenNameRui
person.givenNameSandra
person.identifier159091
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person.identifier.orcid0000-0001-8973-1595
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0001-5384-1469
person.identifier.orcid0000-0003-0970-0575
person.identifier.orcid0000-0003-0221-8508
person.identifier.ridQ-1975-2017
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id35084265300
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id7005010300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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