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Carotid body, insulin, and metabolic diseases: unraveling the links

2014-10-29Review article Acesso aberto
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datacite.subject.fosCiências Médicas::Medicina Básica
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorConde, Sílvia V.
dc.contributor.authorSacramento, Joana F.
dc.contributor.authorGuarino, Maria P.
dc.contributor.authorGonzalez, Constancio
dc.contributor.authorObeso, Ana
dc.contributor.authorDiogo, Lucília N.
dc.contributor.authorMonteiro, Emília C.
dc.contributor.authorRibeiro, Maria J.
dc.date.accessioned2026-05-05T15:34:47Z
dc.date.available2026-05-05T15:34:47Z
dc.date.issued2014-10-29
dc.descriptionArticle number - 418.
dc.description.abstractThe carotid bodies (CB) are peripheral chemoreceptors that sense changes in arterial blood O2, CO2 and pH levels. Hypoxia, hypercapnia and acidosis activate the CB, which respond by increasing the action potential frequency in their sensory nerve, the carotid sinus nerve (CSN). CSN activity is integrated in the brain stem to induce a panoply of cardiorespiratory reflexes aimed, primarily, to normalize the altered blood gases, via hyperventilation, and to regulate blood pressure and cardiac performance, via sympathetic nervous system (SNS) activation. Besides its role in the cardiorespiratory control the CB has been proposed as a metabolic sensor implicated in the control of energy homeostasis and, more recently, in the regulation of whole body insulin sensitivity. Hypercaloric diets cause CB overactivation in rats, which seems to be at the origin of the development of insulin resistance and hypertension, core features of metabolic syndrome and type 2 diabetes. Consistent with this notion, CB sensory denervation prevents metabolic and hemodynamic alterations in hypercaloric feed animal. Obstructive sleep apnoea (OSA) is another chronic disorder characterized by increased CB activity and intimately related with several metabolic and cardiovascular abnormalities. In this manuscript we review in a concise manner the putative pathways linking CB chemoreceptors deregulation with the pathogenesis of insulin resistance and arterial hypertension. Also, the link between chronic intermittent hypoxia (CIH) and insulin resistance is discussed. Then, a final section is devoted to debate strategies to reduce CB activity and its use for prevention and therapeutics of metabolic diseases with an emphasis on new exciting research in the modulation of bioelectronic signals, likely to be central in the future.eng
dc.description.sponsorshipThis work was supported by the Portuguese Foundation for Science and Technology [Grants EXPL/NEU-SCC/2183/2013] and by the L'Oreal/FCT/UNESCO Medals of Honor for Women in Science 2009 (to Sílvia V. Conde) and by Spanish Ministry of Economy and Competitiveness [Grant BFU2012-37459 to Constancio Gonzalez and by Spanish Ministry of Health-Institute Carlos III [CIBERES to Constancio Gonzalez].
dc.description.sponsorshipFCT (Portugal); Spanish Ministry of Economy and Competitiveness; Spanish Ministry of Health-Institute Carlos III.
dc.identifier.citationConde, S. V., Sacramento, J. F., Guarino, M. P., Gonzalez, C., Obeso, A., Diogo, L. N., Monteiro, E. C., & Ribeiro, M. J. (2014). Carotid body, insulin, and metabolic diseases: unraveling the links. Frontiers in Physiology, 5, 418. https://doi.org/10.3389/fphys.2014.00418
dc.identifier.doi10.3389/fphys.2014.00418
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/10400.8/16232
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relationMapping the sympathetic efferent activity in carotid-body mediated insulin resistance
dc.relation.hasversionhttps://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2014.00418/full
dc.relation.ispartofFrontiers in Physiology
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCarotid body
dc.subjectChronic intermittent hypoxia
dc.subjectInsulin resistance
dc.subjectMetabolic dysfunction
dc.subjectObstructive sleep apnea
dc.titleCarotid body, insulin, and metabolic diseases: unraveling the linkseng
dc.typeReview article
dspace.entity.typePublication
oaire.awardNumberEXPL/NEU-SCC/2183/2013
oaire.awardTitleMapping the sympathetic efferent activity in carotid-body mediated insulin resistance
oaire.awardURIhttp://hdl.handle.net/10400.8/16231
oaire.citation.endPage14
oaire.citation.startPage1
oaire.citation.titleFrontiers in Physiology
oaire.citation.volume5
oaire.fundingStreamConcurso de Projetos Exploratórios de IC&DT em todos os Domínios Científicos - 2013
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGuarino
person.givenNameMaria Pedro
person.identifier.ciencia-idF21A-BD01-2D52
person.identifier.orcid0000-0001-6079-1105
person.identifier.ridB-5594-2015
person.identifier.scopus-author-id56348477000
relation.isAuthorOfPublicationf163d4df-1e45-4278-affa-5994f206becf
relation.isAuthorOfPublication.latestForDiscoveryf163d4df-1e45-4278-affa-5994f206becf
relation.isProjectOfPublication105fd323-73fc-4c8b-85c0-bd04145b178c
relation.isProjectOfPublication.latestForDiscovery105fd323-73fc-4c8b-85c0-bd04145b178c

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