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Publication
Relationship between Mediterranean Diet Adherence and Saliva Composition
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Advisor(s)
Abstract(s)
: Dietary polyphenol exposure is known to change protein saliva composition in rodents, but
less is known in humans. The present study aimed to assess the relationship between saliva protein
composition and adherence to Mediterranean Diet (MD) and polyphenol intake levels. Participants
were assessed for their dietary habits, which were converted in Mediterranean adherence level,
according to Mediterranean Diet Adherence Score (MEDAS) score. Total polyphenol and total
flavanol intakes were extrapolated from dietary data, using Phenol explorer database. Whole saliva
was collected, and proteins were separated by SDS-PAGE. Salivary S-type cystatins were highly
expressed in the group with medium adherence to MD, being positively correlated with wine
intake in overweight individuals. The association between salivary amylase and MD adherence also
depended on Body Mass Index (BMI), with a positive association only in normal weight individuals.
Polyphenol intake was positively associated with S-type cystatins levels, particularly when flavanols
were considered separately. These results show that saliva relationship with MD adherence depend
on BMI, suggesting that normal weight and overweight individuals may have different salivary
responses to diet. Moreover, these results reinforce the link between saliva and dietary polyphenols
(flavanols) levels, leading to the hypothesis that salivary proteome can have a role in polyphenol-rich
foods acceptance.
Description
Keywords
Dietary polyphenols Mediterranean diet Salivary amylase Salivary cystatins
Citation
Louro, T.; Simões, C.; Penetra, M.J.; Carreira, L.; Castelo, P.M.; Luis, H.; Moreira, P.; Lamy, E. Relationship between Mediterranean Diet Adherence and Saliva Composition. Nutrients 2021, 13, 1246. https://doi.org/10.3390/nu13041246
Publisher
MDPI