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Detection of QnrB54 and Its Novel Genetic Context in Citrobacter freundii Isolated from a Clinical Case

2015-02Journal article Open access
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg14:Proteger a Vida Marinha
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorCampos, Maria Jorge
dc.contributor.authorPalomo, Gonzalo
dc.contributor.authorHormeño, Lorena
dc.contributor.authorRodrigues, Américo
dc.contributor.authorSánchez-Benito, Rosario
dc.contributor.authorPíriz, Segundo
dc.contributor.authorQuesada, Alberto
dc.date.accessioned2025-09-26T11:10:19Z
dc.date.available2025-09-26T11:10:19Z
dc.date.issued2015-02
dc.descriptionDocument type - Letter to the editor.
dc.descriptionAccepted manuscript posted online 15 December 2014.
dc.description.abstractLETTER Quinolone resistance in Enterobacteriaceae is mediated by mutations in the quinolone resistance-determining regions (QRDR) of topoisomerase genes and/or by plasmid-mediated quinolone resistance determinants (PMQR) such as the qnr genes encoding pentapeptide repeat proteins (1). The qnrB family is represented by 80 different alleles (http://www.lahey.org/qnrStudies/); most of them originated from Citrobacter strains and spread to other Enterobacteriaceae species (2). This work describes the identification of a new allele of the quinolone resistance protein QnrB, QnrB54, in a human clinical isolate of Citrobacter freundii detected in Spain.eng
dc.description.sponsorshipWe thank G. A. Jacoby (Lahey Clinic, Burlington, MA, USA), M. Wang (Fudan University, Shanghai, China), L. Cavaco (National Food Institute, Denmark), K. Yamane (National Institute of Infectious Diseases, Japan), and J. M. Rodríguez-Martínez (Universidad de Sevilla, Seville, Spain) for kindly providing us with positive controls for PCR analysis of the reactions performed with qnrA, qnrB, qnrD, qnrS, qepA, aac(6=)-Ib-cr, and oqXAB. We declare that we have no conflicts of interest. This work was supported by projects AGL2012-39028-C03-03, CTS001, and MIVET.
dc.identifier.citationCampos MJ, Palomo G, Hormeño L, Patrocínio Rodrigues A, SánchezBenito R, Píriz S, Quesada A. 2015. Detection of QnrB54 and its novel genetic context in Citrobacter freundii isolated from a clinical case. Antimicrob Agents Chemother 59:1375–1376. doi:10.1128/AAC.03895-14
dc.identifier.doi10.1128/aac.03895-14
dc.identifier.issn0066-4804
dc.identifier.issn1098-6596
dc.identifier.urihttp://hdl.handle.net/10400.8/14132
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Society for Microbiology
dc.relation.hasversionhttps://journals.asm.org/doi/10.1128/aac.03895-14
dc.relation.ispartofAntimicrobial Agents and Chemotherapy
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCitrobacter freundii
dc.subjectDrug Resistance
dc.subjectHumans
dc.subjectMolecular Sequence Data
dc.subjectQuinolones
dc.titleDetection of QnrB54 and Its Novel Genetic Context in Citrobacter freundii Isolated from a Clinical Caseeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1376
oaire.citation.issue2
oaire.citation.startPage1375
oaire.citation.titleAntimicrobial Agents and Chemotherapy
oaire.citation.volume59
oaire.versionhttp://purl.org/coar/version/c_ab4af688f83e57aa
person.familyNameCampos
person.familyNameRodrigues
person.givenNameMaria Jorge
person.givenNameAmérico
person.identifier174191
person.identifier.ciencia-id2416-7867-2D40
person.identifier.orcid0000-0002-0883-0610
person.identifier.orcid0000-0002-5293-5583
person.identifier.ridE-5591-2014
person.identifier.ridF-9573-2010
person.identifier.scopus-author-id55767069800
person.identifier.scopus-author-id15745701600
relation.isAuthorOfPublication6d1bf3db-fdba-4bea-b65d-94491f841659
relation.isAuthorOfPublication718ad6e8-1d3a-4ce3-9870-e4ed6732c30b
relation.isAuthorOfPublication.latestForDiscovery6d1bf3db-fdba-4bea-b65d-94491f841659

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