Detection of QnrB54 and Its Novel Genetic Context in Citrobacter freundii Isolated from a Clinical Case

Campos, Maria Jorge; Palomo, Gonzalo; Hormeño, Lorena; Rodrigues, Américo; Sánchez-Benito, Rosario; Píriz, Segundo; Quesada, Alberto

http://hdl.handle.net/10400.8/14132

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Authors

Sánchez-Benito, Rosario

Píriz, Segundo

Quesada, Alberto

Abstract(s)

LETTER Quinolone resistance in Enterobacteriaceae is mediated by mutations in the quinolone resistance-determining regions (QRDR) of topoisomerase genes and/or by plasmid-mediated quinolone resistance determinants (PMQR) such as the qnr genes encoding pentapeptide repeat proteins (1). The qnrB family is represented by 80 different alleles (http://www.lahey.org/qnrStudies/); most of them originated from Citrobacter strains and spread to other Enterobacteriaceae species (2). This work describes the identification of a new allele of the quinolone resistance protein QnrB, QnrB54, in a human clinical isolate of Citrobacter freundii detected in Spain.

Description

Document type - Letter to the editor.
Accepted manuscript posted online 15 December 2014.

Keywords

Citrobacter freundii Drug Resistance Humans Molecular Sequence Data Quinolones

URI

http://hdl.handle.net/10400.8/14132

Citation

Campos MJ, Palomo G, Hormeño L, Patrocínio Rodrigues A, SánchezBenito R, Píriz S, Quesada A. 2015. Detection of QnrB54 and its novel genetic context in Citrobacter freundii isolated from a clinical case. Antimicrob Agents Chemother 59:1375–1376. doi:10.1128/AAC.03895-14