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Preserving visual acuity: a compelling 12-year case study of controlling neovascular age-related macular degeneration

2024-03-18Journal article Open access
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dc.contributor.authorTomás, Rita O.
dc.contributor.authorCampos, António
dc.contributor.authorOliveira, Nuno
dc.contributor.authorSoares, Pedro
dc.contributor.authorSousa, João P.
dc.date.accessioned2024-08-27T13:59:37Z
dc.date.available2024-08-27T13:59:37Z
dc.date.issued2024-03-18
dc.description.abstractIntroduction: In neovascular age-related macular degeneration (nAMD) trials, anti-VEGF injection frequency decreases after the first year, while outcomes remain primarily related to the number of injections. To the best of our knowledge, there are no reports of maintaining the best corrected visual acuity (BCVA) for more than 7 years in extension studies. Objective To report a 12-year follow-up of a real-world case of nAMD where BCVA was preserved from declining. Case description A 67-year-old Caucasian female presented to our department in June 2010 due to decreased vision in her left eye (LE) within the preceding months. Examination showed a BCVA of 85 letters (L) in the right eye (RE) and 35 L in the LE. Fundus examination showed drusen in the macula of both eyes. Macular edema, loss of the macular lutein pigment, macular hypo/hyperpigmentation were observed in the LE. A diagnosis of Type 2 choroidal neovascular membrane (CNV) in the LE was established and within two months a Type 1 CNV developed in the RE. She undergone 9 injections of bevacizumab (six) and ranibizumab (three) within the first year of treatment in the LE and seven injections of ranibizumab within the first year in the RE. Results The LE had a mean of 5.2 injections per year, and the RE had a mean of 7.5 injections per year, from 2010 to 2022. RE’s BCVA dropped by 8L (85L to 77L) and central retinal thickness (CRT) increased by 16 μm (276 μm to 292 μm) while LE’s BCVA increased by 28L (35L to 63L) and CRT decreased by 369 μm (680 μm to 311 μm), at the twelfth year. Conclusions Although the final visual outcome depends on baseline BCVA and lesion type or size, the number of injections is paramount in preserving BCVA and achieving favorable functional outcomes in nAMD, even after 12 years of treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTomás, R.O., Campos, A., Oliveira, N. et al. Preserving visual acuity: a compelling 12-year case study of controlling neovascular age-related macular degeneration. BMC Ophthalmol 24, 123 (2024). https://doi.org/10.1186/s12886-024-03387-9pt_PT
dc.identifier.doihttps://doi.org/10.1186/s12886-024-03387-9pt_PT
dc.identifier.issn1471-2415
dc.identifier.other123
dc.identifier.urihttp://hdl.handle.net/10400.8/9933
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-024-03387-9pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNeovascular age-related macular degenerationpt_PT
dc.subjectVisual acuitypt_PT
dc.subjectPro re natapt_PT
dc.subjectTreat and extendpt_PT
dc.subjectNumber of injectionspt_PT
dc.subjectReal-worldpt_PT
dc.titlePreserving visual acuity: a compelling 12-year case study of controlling neovascular age-related macular degenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleBMC Ophthalmologypt_PT
oaire.citation.volume24pt_PT
person.familyNameCampos de Figueiredo
person.givenNameAntónio
person.identifier.ciencia-id4F1C-D822-7CFF
person.identifier.orcid0000-0003-0490-5889
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication175bba2d-e9a5-46df-9f0e-da7cb16f04f1
relation.isAuthorOfPublication.latestForDiscovery175bba2d-e9a5-46df-9f0e-da7cb16f04f1

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