Repository logo
 
Publication

2-Hydroxy-4-methoxybenzaldehyde from<i>Hemidesmus indicus</i>is antagonistic to<i>Staphylococcus epidermidis</i>biofilm formation

2020-06-26Journal article Open access
Simple item page
datacite.subject.fosCiências Agrárias::Agricultura, Silvicultura e Pescas
datacite.subject.fosCiências Naturais::Ciências da Terra e do Ambiente
datacite.subject.fosCiências Agrárias::Biotecnologia Agrária e Alimentar
dc.contributor.authorKannappan, Arunachalam
dc.contributor.authorDurgadevi, Ravindran
dc.contributor.authorSrinivasan, Ramanathan
dc.contributor.authorLagoa, Ricardo José Lucas
dc.contributor.authorPackiavathy, Issac Abraham Sybiya Vasantha
dc.contributor.authorPandian, Shunmugiah Karutha
dc.contributor.authorRavi, Arumugam Veera
dc.date.accessioned2025-09-18T15:16:22Z
dc.date.available2025-09-18T15:16:22Z
dc.date.issued2020-06-26
dc.description.abstractStaphylococcus epidermidis (SE) is an opportunistic nosocomial pathogen that accounts for recalcitrant device-related infections worldwide. Owing to the growing interest in plants and their secondary metabolites targeting bacterial adhesion, this study was intended to uncover the anti-biofilm potential of Hemidesmus indicus and its major constituent 2-hydroxy-4-methoxybenzaldehyde (HMB) against SE. The minimum biofilm inhibitory concentration (MBIC) of H. indicus root extract and HMB were found to be 500 and 250 µg ml−1, respectively. The results of time-dependent biofilm inhibition and mature biofilm disruption assays confirmed that HMB targets initial cell adhesion. Furthermore, interference by HMB in the expression of adhesin genes (icaA, aap and bhp) and biofilm components was associated with an increased susceptibility of SE to oxidative stress and antibiotics. To conclude, this study reports for the first time HMB as a potential drug against SE biofilms.eng
dc.description.sponsorshipThe computational and bioinformatics facility was provided by the Alagappa University, Bioinformatics Infrastructure Facility (funded by DBT, GOI, File No. BT/BI/25/012/2012, BIF). The instrumentation facilities were provided by the Department of Science and Technology-Fund for Improvement in S&T Infrastructure (DST-FIST) (grant no. SR/FST/LSI-639/2015(C)), University Grants Commission- Special Assistance Programme-the Department Research Support (UGC SAP-DRS-II) (grant no. F.5-1/2018/DRS-II (SAP-II)), and the Department of Science and Technology- Promotion of University Research and Scientific Excellence Grant (DST-PURSE) (grant no. SR/PURSE Phase 2/38 (G)). Financial support was rendered through RUSA 2.0 (grant no. F. 24-51/2014-U, Policy [TNMulti-Gen], Department of Education, GoI). Financial assistance was given to AR. Kannappan by the University Grants Commission in the form of an UGC-BSR Fellowship (grant no. F.25-1/2014-15(BSR)/7- 326/2011(BSR)).
dc.identifier.citationKannappan, A., Durgadevi, R., Srinivasan, R., Lagoa, R. J. L., Packiavathy, I. A. S. V., Pandian, S. K., & Veera Ravi, A. (2020). 2-Hydroxy-4-methoxybenzaldehyde from Hemidesmus indicus is antagonistic to Staphylococcus epidermidis biofilm formation. Biofouling, 36(5), 549–563. https://doi.org/10.1080/08927014.2020.1777989.
dc.identifier.doi10.1080/08927014.2020.1777989
dc.identifier.eissn1029-2454
dc.identifier.issn0892-7014
dc.identifier.urihttp://hdl.handle.net/10400.8/14091
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/08927014.2020.1777989
dc.relation.ispartofBiofouling
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAnti-biofilm
dc.subjectHemidesmus indicus
dc.subject2-hydroxy-4-methoxybenzaldehyde
dc.subjectStaphylococcus epidermidis
dc.title2-Hydroxy-4-methoxybenzaldehyde from<i>Hemidesmus indicus</i>is antagonistic to<i>Staphylococcus epidermidis</i>biofilm formationeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage563
oaire.citation.issue5
oaire.citation.startPage549
oaire.citation.titleBiofouling: The Journal of Bioadhesion and Biofilm Research
oaire.citation.volume36
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLagoa
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
relation.isAuthorOfPublication8a139213-9a89-4bd3-93ee-1e332519f96b
relation.isAuthorOfPublication.latestForDiscovery8a139213-9a89-4bd3-93ee-1e332519f96b

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2-Hydroxy-4-methoxybenzaldehyde from Hemidesmus indicus is antagonistic to Staphylococcus epidermidis biofilm formation.pdf
Size:
3.57 MB
Format:
Adobe Portable Document Format
Description:
Staphylococcus epidermidis (SE) is an opportunistic nosocomial pathogen that accounts for recalcitrant device-related infections worldwide. Owing to the growing interest in plants and their secondary metabolites targeting bacterial adhesion, this study was intended to uncover the anti-biofilm potential of Hemidesmus indicus and its major constituent 2-hydroxy-4-methoxybenzaldehyde (HMB) against SE. The minimum biofilm inhibitory concentration (MBIC) of H. indicus root extract and HMB were found to be 500 and 250 µg ml−1, respectively. The results of time-dependent biofilm inhibition and mature biofilm disruption assays confirmed that HMB targets initial cell adhesion. Furthermore, interference by HMB in the expression of adhesin genes (icaA, aap and bhp) and biofilm components was associated with an increased susceptibility of SE to oxidative stress and antibiotics. To conclude, this study reports for the first time HMB as a potential drug against SE biofilms.
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.32 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTG - Artigos em revistas internacionais