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Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies

2022-07Journal article Open access
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dc.contributor.authorMarques da Silva, Dorinda
dc.contributor.authorVideira, Paula Alexandra
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2022-10-03T11:01:25Z
dc.date.issued2022-07
dc.description.abstractExposure to pollution is a worldwide societal challenge participating in the etiology and progression of different diseases. However, the scarce information hinders our understanding of the actual level of human exposure and its specific effects. Inadequate and excessive immune responses underlie diverse chronic diseases. Yet, it is unclear which and how toxicant exposures affect the immune system functions. There is a multiplicity of immunological outcomes and biomarkers being studied in human trials related to exposure to different toxicants but still without clear evidence of their value as biomarkers of exposure or effect. The main aim of this study was to collect scientific evidence and identify relevant immunological biomarkers used at the clinical level for toxicant exposures. We used the platform clinical trials.gov as a database tool. First, we performed a search combining research items related to toxicants and immunological parameters. The resulting117 clinical trials were examined for immune-related outcomes and specific biomarkers evaluated in subjects exposed to occupational and environmental toxicants. After categorization, relevant immunological outcomes and biomarkers were identified related to systemic and airway inflammation, modulation of immune cells, allergy and autoimmunity. In general, the immune markers related to inflammation are more frequently investigated for exposure to pollutants, namely IL-6, C-reactive protein (CRP) and nitric oxide (NO). Nevertheless, the data also indicated that prospective biomarkers of effect are gaining ground and a guiding representation of the established and novel biomarkers is suggested for upcoming trials. Finally, potential protective strategies to mitigate the adverse effects of specific toxicants are underlined for future studies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMarques-da-Silva, Dorinda, Videira, Paula Alexandra & Lagoa, Ricardo (2022). Registered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategies. Environmental Toxicology and Pharmacology, 93, 103886. https://doi.org/10.1016/j.etap.2022.103886.pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.etap.2022.103886pt_PT
dc.identifier.issn1382-6689
dc.identifier.urihttp://hdl.handle.net/10400.8/7751
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.relationPTDC/BIA-MIB/ 31864/2017pt_PT
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1382668922000795?via%3Dihubpt_PT
dc.subjectToxic compoundspt_PT
dc.subjectClinical trialspt_PT
dc.subjectImmunological biomarkerspt_PT
dc.subjectInflammationpt_PT
dc.subjectAllergypt_PT
dc.subjectAutoimmune diseasept_PT
dc.titleRegistered human trials addressing environmental and occupational toxicant exposures: Scoping review of immunological markers and protective strategiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50020%2F2020/PT
oaire.citation.startPage103886pt_PT
oaire.citation.titleEnvironmental Toxicology and Pharmacologypt_PT
oaire.citation.volume93pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameLagoa
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id521A-35C1-078D
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id35751117400
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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