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Rafting on the Evidence for Lipid Raft-like Domains as Hubs Triggering Environmental Toxicants’ Cellular Effects

2023-09-13Recensão Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.fosEngenharia e Tecnologia
datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorLagoa, Ricardo
dc.date.accessioned2026-03-26T13:21:45Z
dc.date.available2026-03-26T13:21:45Z
dc.date.issued2023-09-13
dc.descriptionArticle number - 6598
dc.descriptionThis article belongs to the Special Issue Themed Issue in Honor of Carlos Gutiérrez Merino: Forty Years of Research Excellence in the Field of Membrane Proteins and Bioenergetics.
dc.description.abstractThe plasma membrane lipid rafts are cholesterol- and sphingolipid-enriched domains that allow regularly distributed, sub-micro-sized structures englobing proteins to compartmentalize cellular processes. These membrane domains can be highly heterogeneous and dynamic, functioning as signal transduction platforms that amplify the local concentrations and signaling of individual components. Moreover, they participate in cell signaling routes that are known to be important targets of environmental toxicants affecting cell redox status and calcium homeostasis, immune regulation, and hormonal functions. In this work, the evidence that plasma membrane raft-like domains operate as hubs for toxicants’ cellular actions is discussed, and suggestions for future research are provided. Several studies address the insertion of pesticides and other organic pollutants into membranes, their accumulation in lipid rafts, or lipid rafts’ disruption by polychlorinated biphenyls (PCBs), benzo[a]pyrene (B[a]P), and even metals/metalloids. In hepatocytes, macrophages, or neurons, B[a]P, airborne particulate matter, and other toxicants caused rafts’ protein and lipid remodeling, oxidative changes, or amyloidogenesis. Different studies investigated the role of the invaginated lipid rafts present in endothelial cells in mediating the vascular inflammatory effects of PCBs. Furthermore, in vitro and in vivo data strongly implicate raft-localized NADPH oxidases, the aryl hydrocarbon receptor, caveolin-1, and protein kinases in the toxic mechanisms of occupational and environmental chemicals.eng
dc.description.sponsorshipThis research was funded by Fundação para a Ciência e Tecnologia, LA/P/0045/2020 (ALiCE), UIDB/50020/2020 and UIDP/50020/2020 (LSRE-LCM), funded by national funds through FCT/MCTES(PIDDAC).
dc.identifier.citationMarques-da-Silva, D.; Lagoa, R. Rafting on the Evidence for Lipid Raft-like Domains as Hubs Triggering Environmental Toxicants’ Cellular Effects. Molecules 2023, 28, 6598. https://doi.org/10.3390/ molecules28186598
dc.identifier.doi10.3390/molecules28186598
dc.identifier.eissn1420-3049
dc.identifier.urihttp://hdl.handle.net/10400.8/16011
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationALICE - Associate Laboratory in Chemical Engineering
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relation.hasversionhttps://www.mdpi.com/1420-3049/28/18/6598
dc.relation.ispartofMolecules
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcaveolae
dc.subjectcholesterol
dc.subjectendocrine disruptors
dc.subjectenvironmental toxicology
dc.subjectinflammatory signaling
dc.subjectlipophilic agents
dc.subjectmembrane rafts
dc.subjectpollutants
dc.subjectpolycyclic aromatic hydrocarbons
dc.subjecttoxic agents
dc.titleRafting on the Evidence for Lipid Raft-like Domains as Hubs Triggering Environmental Toxicants’ Cellular Effectseng
dc.typereview
dspace.entity.typePublication
oaire.awardNumberLA/P/0045/2020
oaire.awardNumberUIDB/50020/2020
oaire.awardNumberUIDP/50020/2020
oaire.awardTitleALICE - Associate Laboratory in Chemical Engineering
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0045%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50020%2F2020/PT
oaire.citation.endPage23
oaire.citation.issue18
oaire.citation.startPage1
oaire.citation.titleMolecules
oaire.citation.volume28
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMarques da Silva
person.familyNameLagoa
person.givenNameDorinda
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0003-0460-5421
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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LSRE-LCM - Artigos em Revistas Nacionais e de Circulação Internacional
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