Biofabrication Strategies for Tissue Engineering

Bártolo, Paulo Jorge; Domingos, Marco; Patrício, Tatiana; Cometa, Stefania; Mironov, Vladimir

Publication

Biofabrication Strategies for Tissue Engineering

2011Book part

dc.contributor.author	Bártolo, Paulo Jorge
dc.contributor.author	Domingos, Marco
dc.contributor.author	Patrício, Tatiana
dc.contributor.author	Cometa, Stefania
dc.contributor.author	Mironov, Vladimir
dc.contributor.author	Bártolo, Paulo Jorge
dc.date.accessioned	2025-12-17T19:52:13Z
dc.date.available	2025-12-17T19:52:13Z
dc.date.issued	2011
dc.description.abstract	The success of Tissue Engineering (TE) strongly relies on the capability of designing biomimetic scaffolds closely resembling the host tissue environment. Due to the functional multitude of the native tissues, the considerations are complex and include chemical, morphological, mechanical and biological factors and their mutability with time. Nonetheless, to trigger and/or assist the “natural healing mechanism’’ of the human body it seems essential to provide an appropriate biomechanical environment and biomolecular signalling to the cells. Novel biomanufacturing processes are increasingly being recognized as ideal techniques to produce 3D biodegradable structures with optimal pore size and spatial distribution, providing an adequate mechanical support for tissue regeneration while shaping in-growing tissues. In this chapter, we discuss in detail the most recent advances in the field of biofabrication, providing and updated overview of processes and materials employed in the production of tissue engineering constructs. Bioprinting or ‘’scaffold-less’’ strategies are also presented in this work. They are based on the precise deposition of high-density tissue spheroids or cell aggregates being advantageous alternatives to the current scaffold-based tissue engineering approach.	eng
dc.identifier.citation	Bártolo, P.J., Domingos, M., Patrício, T., Cometa, S., Mironov, V. (2011). Biofabrication Strategies for Tissue Engineering. In: Fernandes, P., Bártolo, P. (eds) Advances on Modeling in Tissue Engineering. Computational Methods in Applied Sciences, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1254-6_8
dc.identifier.doi	10.1007/978-94-007-1254-6_8
dc.identifier.isbn	9789400712539
dc.identifier.isbn	9789400712546
dc.identifier.issn	1871-3033
dc.identifier.uri	http://hdl.handle.net/10400.8/15143
dc.language.iso	eng
dc.peerreviewed	yes
dc.publisher	Springer Netherlands
dc.relation.hasversion	https://link.springer.com/chapter/10.1007/978-94-007-1254-6_8
dc.relation.ispartof	Computational Methods in Applied Sciences
dc.relation.ispartof	Advances on Modeling in Tissue Engineering
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title	Biofabrication Strategies for Tissue Engineering	eng
dc.type	book part
dspace.entity.type	Publication
oaire.citation.endPage	176
oaire.citation.startPage	137
oaire.citation.title	Computational Methods in Applied Sciences
oaire.version	http://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyName	Domingos
person.familyName	Fernandes Patrício
person.familyName	Bartolo
person.givenName	Marco
person.givenName	Tatiana Marisa
person.givenName	Paulo
person.identifier	L-2781-2015
person.identifier	203086
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person.identifier.orcid	0000-0002-6693-790X
person.identifier.orcid	0000-0003-0672-9014
person.identifier.orcid	0000-0003-3683-726X
person.identifier.rid	F-2421-2013
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