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Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials

2022Journal article Restricted access
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dc.contributor.authorMachado, Pedro
dc.contributor.authorMorgado, Miguel
dc.contributor.authorRaposo, João
dc.contributor.authorMendes, Marco
dc.contributor.authorSilva, Cândida G.
dc.contributor.authorMorais, Nuno
dc.date.accessioned2022-07-05T12:56:26Z
dc.date.available2022-07-05T12:56:26Z
dc.date.issued2022
dc.description.abstractPurpose: To investigate the effects of exercise training on cancer-related fatigue (CRF) in colorectal cancer survivors. Methods: Randomized controlled trials published between 1 January 2010 and 19 October 2020, selected through online search conducted in PubMed, Scopus, Web of Science, SPORTDiscus and PEDro databases, were included. Eligible trials compared the effect of exercise training interventions, versus non-exercise controls on CRF, in colorectal cancer survivors, during or after treatment. The methodological quality of individual studies was analysed using the Physiotherapy Evidence Database (PEDro) scale. Standardized mean differences (SMD) that were pooled using random-effects models were included as the effect size. In addition, 95% prediction intervals (PI) were calculated. Results: Six trials involving 330 colorectal cancer patients met the inclusion criteria and presented reasonable to good methodological quality. An overall small-to-moderate effect of exercise training on CRF was found (SMD = - 0.29: 95% CI: [- 0.53; - 0.06]; p = 0.01; PI: [- 0.63; 0.04]; low-quality evidence). Subgroup analysis revealed moderate effects of exercise interventions performed during chemotherapy (SMD = - 0.63; 95% CI: [- 1.06; - 0.21]; p = 0.003) and small, non-significant effects, when exercise training was performed after cancer treatment (SMD = - 0.14; 95% CI: [- 0.43; 0.14]; p = 0.32). Steady improvements were achieved when a combination of aerobic plus resistance exercise was used, in interventions lasting 12 to 24 weeks. Conclusion: Exercise training could be regarded as a supportive therapy for the clinical management of CRF in colorectal cancer patients undergoing chemotherapy, but further studies are necessary to clarify the effects of exercise interventions on CRF after cancer treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMachado P, Morgado M, Raposo J, Mendes M, Silva CG, Morais N. Effectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trials. Support Care Cancer. 2022;30(7):5601-5613. doi:10.1007/s00520-022-06856-3pt_PT
dc.identifier.doi10.1007/s00520-022-06856-3pt_PT
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.urihttp://hdl.handle.net/10400.8/7327
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationCenter for Innovative Care and Health Technology
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectRehabilitationpt_PT
dc.subjectExercise trainingpt_PT
dc.subjectFatiguept_PT
dc.subjectOncologypt_PT
dc.subjectPhysical activitypt_PT
dc.titleEffectiveness of exercise training on cancer-related fatigue in colorectal cancer survivors: a systematic review and meta-analysis of randomized controlled trialspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.citation.endPage5613pt_PT
oaire.citation.issue7pt_PT
oaire.citation.startPage5601pt_PT
oaire.citation.titleSupportive Care in Cancerpt_PT
oaire.citation.volume30pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMachado
person.familyNameMorgado
person.familyNameRaposo
person.familyNameMendes
person.familyNameSilva
person.familyNameValente Morais
person.givenNamePedro
person.givenNameMiguel Ângelo
person.givenNameJoão
person.givenNameMarco
person.givenNameCândida
person.givenNameNuno Alexandre
person.identifier1763199
person.identifierR_whtEEAAAAJ
person.identifier.ciencia-id111A-3F47-19CD
person.identifier.ciencia-idD513-D305-7FD1
person.identifier.ciencia-id7D15-1925-242F
person.identifier.orcid0000-0003-1147-2778
person.identifier.orcid0000-0001-6478-8886
person.identifier.orcid0000-0001-7599-7480
person.identifier.orcid0000-0001-7922-4282
person.identifier.orcid0000-0002-7092-1169
person.identifier.orcid0000-0002-8209-3719
person.identifier.scopus-author-id55429869600
person.identifier.scopus-author-id55317141300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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