Repository logo
 
Publication

Antimicrobial and antileukemic effects: in vitro activity of Calyptranthes grandifolia aqueous leaf extract

2020Journal article Restricted access
Simple item page
dc.contributor.authorMajolo, Fernanda
dc.contributor.authorBitencourt, Shanna
dc.contributor.authorMonteiro, Bruna Wissmann
dc.contributor.authorHaute, Gabriela Viegas
dc.contributor.authorAlves, Celso
dc.contributor.authorSilva, Joana
dc.contributor.authorPinteus, Susete
dc.contributor.authorSantos, Roberto Christ Vianna
dc.contributor.authorTorquato, Heron Fernandes Vieira
dc.contributor.authorParedes-Gamero, Edgar Julian
dc.contributor.authorOliveira, Jarbas Rodrigues
dc.contributor.authorSouza, Claucia Fernanda Volken De
dc.contributor.authorPedrosa, Rui
dc.contributor.authorLaufer, Stefan
dc.contributor.authorGoettert, Márcia Inês
dc.date.accessioned2020-08-17T15:17:27Z
dc.date.available2020-08-17T15:17:27Z
dc.date.issued2020
dc.description.abstractNatural products are still a promising source of bioactive molecules. Food and Drug Administration data showed that approximately 49% of the approved molecules originate naturally or chemicallyresemble these substances, of which more than 70% are being used in anticancer therapy. It is noteworthy that at present there are no scientific studies to prove the effectiveness and safety of a number of plants used in folk medicine such as in the case of Calyptranthes grandifolia O. Berg (Myrtaceae) originally from South America. The aim of the present study was to determine the biological potential and toxicological effects of the aqueous leaf extract of C. grandifolia. The main detected phytoconstituents were condensed tannins and flavonoids and a high quantity of polyphenols. Regarding the antimicrobial potential, the extract exerted inhibitory activity against Pseudomonas aeruginosa. The results also revealed the extract induced DNA damage in a concentration-dependent manner in RAW 264.7 cells. In addition, C. grandifolia produced cytotoxicity in leukemia cell lines (HL60 and Kasumi-1) without affecting isolated human lymphocytes but significantly inhibited JAK3 and p38α enzyme activity. Taken together, these findings add important information on the biological and toxicological effects of C. grandifolia, indicating that aqueous extract may be a source of natural antimicrobial and antileukemic constituents.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernanda Majolo , Shanna Bitencourt , Bruna Wissmann Monteiro , Gabriela Viegas Haute , Celso Alves , Joana Silva , Susete Pinteus , Roberto Christ Vianna Santos , Heron Fernandes Vieira Torquato , Edgar Julian Paredes-Gamero , Jarbas Rodrigues Oliveira , Claucia Fernanda Volken De Souza , Rui Felipe Pinto Pedrosa , Stefan Laufer & Márcia Inês Goettert (2020) Antimicrobial and antileukemic effects: in vitro activity of Calyptranthes grandifolia aqueous leaf extract, Journal of Toxicology and Environmental Health, Part A, 83:8, 289-301, DOI: 10.1080/15287394.2020.1753606pt_PT
dc.identifier.doi10.1080/15287394.2020.1753606pt_PT
dc.identifier.issn1528-7394
dc.identifier.issn1087-2620
dc.identifier.urihttp://hdl.handle.net/10400.8/5095
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntibacterialpt_PT
dc.subjectBioactive natural productspt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectLeukemiapt_PT
dc.subjectMyrtaceaept_PT
dc.titleAntimicrobial and antileukemic effects: in vitro activity of Calyptranthes grandifolia aqueous leaf extractpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage301pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage289pt_PT
oaire.citation.titleJournal of Toxicology and Environmental Health, Part A: Current Issuespt_PT
oaire.citation.volume83pt_PT
person.familyNameAlves
person.familyNameSilva
person.familyNamePinteus
person.familyNamePedrosa
person.givenNameCelso
person.givenNameJoana
person.givenNameSusete
person.givenNameRui
person.identifier159091
person.identifier98885
person.identifier159292
person.identifier349272
person.identifier.ciencia-id501C-F268-2E60
person.identifier.ciencia-id6317-6F15-BA35
person.identifier.ciencia-id661E-9677-74C5
person.identifier.ciencia-id3817-33DE-919E
person.identifier.orcid0000-0003-1581-2127
person.identifier.orcid0000-0003-1224-1699
person.identifier.orcid0000-0002-3290-3111
person.identifier.orcid0000-0003-0970-0575
person.identifier.ridB-3366-2017
person.identifier.ridB-4815-2015
person.identifier.scopus-author-id55654969100
person.identifier.scopus-author-id56370819800
person.identifier.scopus-author-id55655328300
person.identifier.scopus-author-id7005010300
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationba5ab7c2-7474-4ea9-9bf0-ca15fe42809a
relation.isAuthorOfPublication23e68f76-0f7a-4f39-9da8-f1a26e2e2cd7
relation.isAuthorOfPublicationdb45e9a7-9e25-4fbf-903e-9feac4a23d61
relation.isAuthorOfPublication94496a40-57cf-472f-94e1-5db9d5da78b6
relation.isAuthorOfPublication.latestForDiscoverydb45e9a7-9e25-4fbf-903e-9feac4a23d61

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Majolo et al_2020_Journal of Toxicology and Environmental Health, Part A.pdf
Size:
1.93 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

MARE - Artigos com peer review
ESTM - Artigos em revistas internacionais