Repository logo
 
Publication

Celiac disease gut microbiome studies in the third millennium: reviewing the findings and gaps of available literature

2024-09-16Journal article Open access
Simple item page
dc.contributor.authorLuz, Vanessa C. C.
dc.contributor.authorPereira, Sónia Gonçalves
dc.date.accessioned2024-10-18T16:04:21Z
dc.date.available2024-10-18T16:04:21Z
dc.date.issued2024-09-16
dc.date.updated2024-10-17T08:56:08Z
dc.descriptionFunding: The authors declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by a 2022 Beyond Celiac Established Investigator Award (BeyondCeliac.org). SP acknowledges the Fundação para a Ciência e Tecnologia for her direct funding (CEECINST/00051/2018; https://doi.org/10.54499/CEECINST/00051/2018/CP1566/CT0004) and that of her research unit (UIDB/05704/2020). Both authors acknowledge Maratona da Saúde, under the Autoimmune and Allergies 17/18 Prize. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptpt_PT
dc.description.abstractCeliac disease is an autoimmune enteropathy caused by the ingestion of minute amounts of gluten in a subset of genetically predisposed individuals. Its onset occurs at different ages and with variable symptoms. The gut microbiome may contribute to this variability. This review aims to provide an overview of the available research on celiac disease gut microbiome and identify the knowledge gap that could guide future studies. Following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis extension for Scoping Reviews (PRISMA-ScR), four electronic databases were searched for literature from January 2000 to July 2023 addressing celiac disease gut microbiome characterization using next-generation sequencing (NGS) approaches. From the 489 publications retrieved, 48 publications were selected and analyzed, focusing on sample characterization (patients, controls, and tissues) and methodologies used for NGS microbiome analysis and characterization. The majority of the selected publications regarded children and adults, and four were randomized clinical trials. The number of participants per study greatly varied and was typically low. Feces were the most frequently tested sample matrix, and duodenal samples were analyzed in one-third of the studies. Incomplete and diverse information on the methodological approaches and gut microbiome results was broadly observed. While similar trends regarding the relative abundance of some phyla, such as Pseudomonadota (former Proteobacteria), were detected in some studies, others contradicted those results. The observed high variability of technical approaches and possibly low power and sample sizes may prevent reaching a consensus on celiac disease gut microbiome composition. Standardization of research protocols to allow reproducibility and comparability is required, as interdisciplinary collaborations to further data analysis, interpretation, and, more importantly, health outcome prediction or improvement.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLuz VCC, Pereira SG. Celiac disease gut microbiome studies in the third millennium: reviewing the findings and gaps of available literature. Front Med Technol. 2024 Sep 16;6:1413637. doi: 10.3389/fmedt.2024.1413637.pt_PT
dc.identifier.doihttps://doi.org/10.3389/fmedt.2024.1413637pt_PT
dc.identifier.eissn2673-3129
dc.identifier.issn2673-3129
dc.identifier.slugcv-prod-4171210
dc.identifier.urihttp://hdl.handle.net/10400.8/10187
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationNot Available
dc.relationNot Available
dc.relation.publisherversionhttps://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2024.1413637/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectceliac diseasept_PT
dc.subjectgut microbiomept_PT
dc.subjectgut microbiotapt_PT
dc.subjectautoimmunitypt_PT
dc.subjectnext-generationpt_PT
dc.subjectsequencingpt_PT
dc.subjectPRISMA-ScRpt_PT
dc.titleCeliac disease gut microbiome studies in the third millennium: reviewing the findings and gaps of available literaturept_PT
dc.title.alternativeVanessa C. C. Luz and Sónia Gonçalves Pereira*pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00051%2F2018%2FCP1566%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00051%2F2018%2FCP1566%2FCT0004/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F05704%2F2020/PT
oaire.citation.endPage19pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Medical Technologypt_PT
oaire.citation.volume6pt_PT
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
person.familyNameGonçalves Pereira
person.givenNameSónia
person.identifier461252
person.identifier.ciencia-idEB1F-4DB2-B0C9
person.identifier.orcid0000-0001-8197-1850
person.identifier.ridM-7588-2017
person.identifier.scopus-author-id7202024712
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid8615-92D1-7858 | Sónia Gonçalves Pereira
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication259ad2cc-f9ff-4c33-ad6d-10f5b3ff341a
relation.isAuthorOfPublication.latestForDiscovery259ad2cc-f9ff-4c33-ad6d-10f5b3ff341a
relation.isProjectOfPublication79a941dc-2813-4f89-850b-4228ff5224cc
relation.isProjectOfPublication22772ec7-f646-4835-8b02-8640752aeb62
relation.isProjectOfPublicationfe5c880e-a8b7-4dc2-8ec2-70f7b09c0496
relation.isProjectOfPublication.latestForDiscovery79a941dc-2813-4f89-850b-4228ff5224cc

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
FMT_-_CD_microbiome_review.pdf
Size:
9.99 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.33 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ciTechCare - Artigos
ESSLei - Artigos em revistas internacionais