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Racial and Socioeconomic Disparity in Breast Cancer Mortality: A Systematic Review and Meta-Analysis

2025-05-13Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorRibeiro, Helena Fiats
dc.contributor.authorPelloso, Fernando Castilho
dc.contributor.authorFonseca, Beatriz Sousa da
dc.contributor.authorCamparoto, Camila Wohlenberg
dc.contributor.authorCarvalho, Maria Dalva de Barros
dc.contributor.authorMarques, Vlaudimir Dias
dc.contributor.authorBitencourt, Mariá Romanio
dc.contributor.authorStevanato, Kely Paviani
dc.contributor.authorBorba, Pedro Beraldo
dc.contributor.authorBorghesan, Deise Helena Pelloso
dc.contributor.authorEgger, Paulo Acácio
dc.contributor.authorAlarcão, Ana Carolina Jacinto
dc.contributor.authorCuman, Roberto Kenji Nakamura
dc.contributor.authorHuber, Isabella Morais Tavares
dc.contributor.authorConsolaro, Márcia Edilaine Lopes
dc.contributor.authorPujals, Constanza
dc.contributor.authorLaranjeira, Carlos
dc.contributor.authorPedroso, Raíssa Bocchi
dc.contributor.authorPelloso, Sandra Marisa
dc.date.accessioned2025-07-31T14:04:06Z
dc.date.available2025-07-31T14:04:06Z
dc.date.issued2025-05-13
dc.descriptionArticle number - 1641
dc.descriptionThis article belongs to the Special Issue Socio-Demographic Factors and Cancer Research
dc.description.abstractBackground/Objectives: Breast cancer is one of the leading causes of female mortality worldwide, but significant racial and socioeconomic disparities persist in disease outcomes. This review aimed to analyze racial and socioeconomic inequalities in mortality and survival from breast cancer, identifying the impact of social risk factors on access to diagnosis and treatment. Methods: A systematic literature review and meta-analysis was performed following PRISMA guidelines. Eighteen studies published between 2014 and 2024 were included, with 11 contributing to the meta-analysis. Random-effect models were used to assess correlations between socioeconomic status, race, and clinical outcomes, including heterogeneity and publication bias analyses. Results: The strongest associations were observed between income, race, and breast cancer survival, with survival significantly worse among Black women and low-income populations (p < 0.001). Income also showed a strong positive correlation with clinical outcomes. In contrast, the overall effect on mortality was not statistically significant (p = 0.290), likely due to high heterogeneity across studies (I2 = 100%). These findings suggest that structural disparities in access to healthcare and early detection substantially affect survival rates. Conclusions: Racial and socioeconomic disparities in breast cancer outcomes remain critical public health challenges. Targeted policies to expand early diagnosis and ensure equitable access to effective treatment are essential to reduce these disparities and improve survival in underserved populations.eng
dc.description.sponsorshipThis work was supported by the Coordination for the Improvement of Higher Education Personnel (CAPES) (financial code 001). This work is also supported by national funds through FCT—Fundação para a Ciência e a Tecnologia, I.P. (UIDB/05704/2020 and UIDP/05704/2020) and under the Scientific Employment Stimulus-Institutional Call (https://doi.org/10.54499/CEECINST/00051/2018/CP1566/CT0012, accessed on 19 April 2025).
dc.identifier.citationRibeiro, H.F.; Pelloso, F.C.; Fonseca, B.S.d.; Camparoto, C.W.; Carvalho, M.D.d.B.; Marques, V.D.; Bitencourt, M.R.; Stevanato, K.P.; Borba, P.B.; Borghesan, D.H.P.; et al. Racial and Socioeconomic Disparity in Breast Cancer Mortality: A Systematic Review and Meta-Analysis. Cancers 2025, 17, 1641. https://doi.org/ 10.3390/cancers17101641
dc.identifier.doi10.3390/cancers17101641
dc.identifier.issn2072-6694
dc.identifier.urihttp://hdl.handle.net/10400.8/13820
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationCenter for Innovative Care and Health Technology
dc.relationUIDP/05704/2020
dc.relation.hasversionhttps://www.mdpi.com/2072-6694/17/10/1641
dc.relation.ispartofCancers
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectSocioeconomic disparity
dc.subjectCulture-specific cancer outcomes
dc.subjectBreast cancer
dc.titleRacial and Socioeconomic Disparity in Breast Cancer Mortality: A Systematic Review and Meta-Analysiseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Care and Health Technology
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F05704%2F2020/PT
oaire.citation.issue10
oaire.citation.titleCarcinogenesis: Integrative Cancer Research
oaire.citation.volume17
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLaranjeira
person.givenNameCarlos
person.identifier.orcid0000-0003-1080-9535
person.identifier.scopus-author-id22957802900
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication7c2157d8-cac9-4004-9438-e92fec260842
relation.isAuthorOfPublication.latestForDiscovery7c2157d8-cac9-4004-9438-e92fec260842
relation.isProjectOfPublicationd421b07d-3471-4026-aa43-def80b8e142b
relation.isProjectOfPublication.latestForDiscoveryd421b07d-3471-4026-aa43-def80b8e142b

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