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Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer

2018Journal article Open access
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dc.contributor.authorAlves, Celso
dc.contributor.authorPinteus, Susete
dc.contributor.authorRodrigues, Ana
dc.contributor.authorHorta, André
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2020-06-30T15:24:08Z
dc.date.available2020-06-30T15:24:08Z
dc.date.issued2018
dc.descriptionThis study had the support of the Fundação para a Ciência e a Tecnologia (FCT) through Red2Discovery Project (PTDC/MAR‑BIO/6149/2014), co‑financed by COMPETE (POCI‑01‑0145‑FEDER‑016791), and Strategic Project UID/MAR/04292/2013 granted to MARE and the support of the FP7 EU project “BAMMBO: Sustainable Production of Biologically Active Molecules of Marine Based Origin” (FP7 n 265896/http//www.bammbo. eu). C.A, S.P. and A.H. are financially supported by a grant from FCT Fundação para a Ciência e Tecnologia (SFRH/BD/97764/2013, SFRH/ BD/96203/2013 and SFRH/BD/120250/2016, respectively).
dc.description.abstractBackground: The marine environment has shown to be an interesting source of new antitumor agents, representing an important tool in cancer research. Objective: The aim of this study was to evaluate the antitumor activities of 12 algae from Peniche coast (Portugal) on an in vitro model of human colorectal cancer (Caco‑2 cells). Materials and Methods: The antitumor potential was accessed by evaluating Caco‑2 cell’s viability and proliferation through the 3‑[4, 5‑dimethylthiazol‑2‑yl]‑2, 5‑diphenyl tetrazolium bromide and calcein‑AM methods. Results: The dichloromethane extracts of Asparagopsis armata and Sphaerococcus coronopifolius induced the highest decrease on cell’s viability (1 mg/mL; 24 h), 98.96% ± 0.39% and 98.08% ± 0.89%, respectively, followed by the methanolic extracts of S. coronopifolius (96.47% ± 1.26%) and A. armata (92.68% ± 1.17%). Regarding cell proliferation, the highest decrease of Caco‑2 cell’s proliferation (1 mg/mL; 24 h) was induced by the dichloromethane extract of A. armata (100% ± 0.48%), S. coronopifolius (99.04 ± 0.51%), and Plocamium cartilagineum (95.05% ± 1.19%). The highest potency was shown by the dichloromethane extract of S. coronopifolius in both, cytotoxicity and antiproliferative tests, with an IC50 of 21.3 and 36.5 µg/mL, respectively. Conclusion: The extracts of A. armata and S. coronopifolius are promising sources of new bioactive molecules with application in cancer therapeutics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves C, Pinteus S, Rodrigues A, Horta A, Pedrosa R. Algae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancer. Phcog Res 2018;10:24-30.pt_PT
dc.identifier.doi10.4103/pr.pr_151_16pt_PT
dc.identifier.issn0976-4836
dc.identifier.urihttp://hdl.handle.net/10400.8/4973
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMedknow Publicationspt_PT
dc.relationEvaluation of the benefit/risk associated to the consumption of seaweed based on the bioaccessibility/bioavailability of omega 3 fatty acids, essential elements, antioxidant compounds and contaminants
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectCaco‑2 cellspt_PT
dc.subjectMarine natural productspt_PT
dc.subjectRed macroalgaept_PT
dc.subjectSeaweedpt_PT
dc.titleAlgae from Portuguese Coast Presented High Cytotoxicity and Antiproliferative Effects on an In vitro Model of Human Colorectal Cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEvaluation of the benefit/risk associated to the consumption of seaweed based on the bioaccessibility/bioavailability of omega 3 fatty acids, essential elements, antioxidant compounds and contaminants
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMAR%2F04292%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F97764%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F96203%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F120250%2F2016/PT
oaire.citation.endPage30pt_PT
oaire.citation.startPage24pt_PT
oaire.citation.titlePharmacognosy Researchpt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream5876
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNameAlves
person.familyNamePinteus
person.familyNameHorta
person.familyNamePedrosa
person.givenNameCelso
person.givenNameSusete
person.givenNameAndré
person.givenNameRui
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project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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