Detection of plasmid mediated colistin resistance (MCR-1) in Escherichia coli and Salmonella enterica isolated from poultry and swine in Spain

Recent findings suggest that use of colistin as a last resort antibiotic is seriously threatened by the rise of a new plasmid mediated mechanism of resistance (MCR-1). This work identifies, for the first time in Southern Europe, the gene mcr-1 in nine strains from farm animals (poultry and swine) corresponding to five Escherichia coli and four Salmonella enterica, amongwhich three belong to serovar Typhimuriumand one to Rissen. TheMCR-1 was found encoded by a plasmid highly mobilizable by conjugation to the E. coli J53 strain. Two E. coli strains carried two determinants, mcr-1 plus pmrA or pmrB mutations, known to confer colistin resistance.

Palavras-chave

Colistin resistance mcr-1 PmrAB Plasmid S. enterica E. coli

URI

http://hdl.handle.net/10400.8/13170

Citação

Quesada A, Ugarte-Ruiz M, Iglesias MR, Porrero MC, Martínez R, Florez-Cuadrado D, Campos MJ, García M, Píriz S, Sáez JL, Domínguez L. Detection of plasmid mediated colistin resistance (MCR-1) in Escherichia coli and Salmonella enterica isolated from poultry and swine in Spain. Res Vet Sci. 2016 Apr;105:134-5. doi: 10.1016/j.rvsc.2016.02.003

Editora

Elsevier BV

DOI

10.1016/j.rvsc.2016.02.003

Coleções

MARE - Artigos com peer review
ESTM - Artigos em revistas internacionais

Licença CC

cclicense-by-nc-nd

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