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Improved osteoblast cell affinity on plasma-modified 3-D extruded PCL scaffolds

2013-04Artigo científico Acesso restrito
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datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorDomingos, M.
dc.contributor.authorIntranuovo, F.
dc.contributor.authorGloria, A.
dc.contributor.authorGristina, R.
dc.contributor.authorAmbrosio, L.
dc.contributor.authorBártolo, P. J.
dc.contributor.authorFavia, P.
dc.date.accessioned2026-03-25T11:42:14Z
dc.date.available2026-03-25T11:42:14Z
dc.date.issued2013-04
dc.description.abstractCellular adhesion and proliferation inside three-dimensional synthetic scaffolds represent a major challenge in tissue engineering. Besides the surface chemistry of the polymers, it is well recognized that scaffold internal architecture, namely pore size/shape and interconnectivity, has a strong effect on the biological response of cells. This study reports for the first time how polycaprolactone (PCL) scaffolds with controlled micro-architecture can be effectively produced via bioextrusion and used to enhance the penetration of plasma deposited species. Low-pressure nitrogen-based coatings were employed to augment cell adhesion and proliferation without altering the mechanical properties of the structures. X-ray photoelectron spectroscopy carried out on different sections of the scaffolds indicates a uniform distribution of nitrogen-containing groups throughout the entire porous structure. In vitro biological assays confirm that plasma deposition sensitively promotes the activity of Saos-2 osteoblast cells, leading to a homogeneous colonization of the PCL scaffolds.eng
dc.description.sponsorshipThe authors are grateful for the financial support provided by the Fundação para a Ciência e Tecnologia through the strategic project Pest-OE/EME/UI4044/2011. Professor Geoffrey Mitchell and his group from CFAM are greatly acknowledged for their support in recording SEM images. Mr. Savino Cosmai (IMIP-CNR, Bari, Italy) is acknowledged for his technical support.
dc.identifier.citationM. Domingos, F. Intranuovo, A. Gloria, R. Gristina, L. Ambrosio, P.J. Bártolo, P. Favia, Improved osteoblast cell affinity on plasma-modified 3-D extruded PCL scaffolds, Acta Biomaterialia, Volume 9, Issue 4, 2013, Pages 5997-6005, ISSN 1742-7061, https://doi.org/10.1016/j.actbio.2012.12.031.
dc.identifier.doi10.1016/j.actbio.2012.12.031
dc.identifier.issn1742-7061
dc.identifier.urihttp://hdl.handle.net/10400.8/15990
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S1742706113000056?via%3Dihub
dc.relation.ispartofActa Biomaterialia
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectTissue engineering
dc.subjectBiofabrication
dc.subjectScaffolds
dc.subjectSurface modification
dc.subjectOsteoblast cells
dc.titleImproved osteoblast cell affinity on plasma-modified 3-D extruded PCL scaffoldseng
dc.typejournal article
dcterms.referenceshttp://dx.doi.org/10.1016/j.actbio.2012. 12.031
dspace.entity.typePublication
oaire.awardNumberPEst-OE/EME/UI4044/2011
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.citation.endPage6005
oaire.citation.issue4
oaire.citation.startPage5997
oaire.citation.titleActa Biomaterialia
oaire.citation.volume9
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDomingos
person.familyNameBartolo
person.givenNameMarco
person.givenNamePaulo
person.identifier203086
person.identifier.ciencia-idB512-2D06-5897
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-6693-790X
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication1fb3bd4b-f499-4db6-93c1-3a671f116d07
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscovery1fb3bd4b-f499-4db6-93c1-3a671f116d07
relation.isProjectOfPublication44bd1c93-9ee1-4685-a408-c2baa61ffbcd
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