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Proteins in ecotoxicology – How, why and why not?

2010-02Journal article Restricted access
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datacite.subject.fosCiências Naturais::Ciências Biológicas
datacite.subject.sdg02:Erradicar a Fome
datacite.subject.sdg08:Trabalho Digno e Crescimento Económico
datacite.subject.sdg15:Proteger a Vida Terrestre
dc.contributor.authorLemos, Marco F.L.
dc.contributor.authorSoares, Amadeu M. V. M.
dc.contributor.authorCorreia, António C.
dc.contributor.authorEsteves, Ana C.
dc.date.accessioned2025-12-15T18:47:53Z
dc.date.available2025-12-15T18:47:53Z
dc.date.issued2010-02
dc.description.abstractThe growing interest in the application of proteomic technologies to solve toxicology issues and its relevance in ecotoxicology research has resulted in the emergence of "ecotoxicoproteomics". There is a general consensus that ecotoxicoproteomics is a powerful tool to spot early molecular events involved in toxicant responses, which are responsible for the adverse effects observed at higher levels of biological organization, thus contributing to elucidate the mode of action of stressors and to identify specific biomarkers. Ultimately, early-warning indicators can then be developed and deployed in "in situ" bioassays and in environmental risk assessment. The number of field experiments or laboratory trials using ecologically relevant test-species and involving proteomics has been, until recently, insufficient to allow a critical analysis of the real benefits of the application of this approach to ecotoxicology. This article intends to present an overview on the applications of proteomics in the context of ecotoxicology, focusing mainly on the prospective research to be done in invertebrates. Although these represent around 95% of all animal species and in spite of the key structural and functional roles they play in ecosystems, proteomic research in invertebrates is still in an incipient stage. We will review applications of ecotoxicoproteomics by evaluating the technical methods employed, the organisms and the contexts studied, the advances achieved until now and lastly the limitations yet to overcome will be discussed.eng
dc.description.sponsorshipThis work was funded by a fellowship provided to AC Esteves (BPD-38008/2007) by Fundação Portuguesa para a Ciência e Tecnologia. Parts of this work were supported by FCT Project Grant reference PTDC/BIA-BDE/75690/2006.
dc.identifier.citationLemos, M.F.L., Soares, A.M.V.M., Correia, A.C. and Esteves, A.C. (2010), Proteins in ecotoxicology – How, why and why not?. Proteomics, 10: 873-887. https://doi.org/10.1002/pmic.200900470.
dc.identifier.doi10.1002/pmic.200900470
dc.identifier.eissn1615-9861
dc.identifier.issn1615-9853
dc.identifier.urihttp://hdl.handle.net/10400.8/15074
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relationDisrupTox - Edaphic Endocrine Disruption Assessment Tool Box
dc.relation.hasversionhttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/pmic.200900470
dc.relation.ispartofPROTEOMICS
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAnimal proteomics
dc.subjectBiomarkers
dc.subjectEcotoxicoproteomics
dc.subjectEnvironmental proteomics
dc.subjectInvertebrates
dc.subjectToxicant mode of action
dc.titleProteins in ecotoxicology – How, why and why not?eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDisrupTox - Edaphic Endocrine Disruption Assessment Tool Box
oaire.awardURIhttp://hdl.handle.net/10400.8/15073
oaire.citation.endPage887
oaire.citation.issue4
oaire.citation.startPage873
oaire.citation.titleProteomics: Proteomics and Systems Biology
oaire.citation.volume10
oaire.fundingStreamConcurso para Projectos de I&D em todos os Domínios Científicos - 2006
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLemos
person.givenNameMarco
person.identifier996337
person.identifier.ciencia-id971F-ACCA-C0D1
person.identifier.orcid0000-0001-9887-1864
person.identifier.ridF-7951-2011
person.identifier.scopus-author-id7006042884
relation.isAuthorOfPublicationf21e5540-df76-43e9-ad64-93edd70da1f1
relation.isAuthorOfPublication.latestForDiscoveryf21e5540-df76-43e9-ad64-93edd70da1f1
relation.isProjectOfPublication79dfac64-43cc-4f79-b8ed-0fee87d28a64
relation.isProjectOfPublication.latestForDiscovery79dfac64-43cc-4f79-b8ed-0fee87d28a64

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The growing interest in the application of proteomic technologies to solve toxicology issues and its relevance in ecotoxicology research has resulted in the emergence of "ecotoxicoproteomics". There is a general consensus that ecotoxicoproteomics is a powerful tool to spot early molecular events involved in toxicant responses, which are responsible for the adverse effects observed at higher levels of biological organization, thus contributing to elucidate the mode of action of stressors and to identify specific biomarkers. Ultimately, early-warning indicators can then be developed and deployed in "in situ" bioassays and in environmental risk assessment. The number of field experiments or laboratory trials using ecologically relevant test-species and involving proteomics has been, until recently, insufficient to allow a critical analysis of the real benefits of the application of this approach to ecotoxicology. This article intends to present an overview on the applications of proteomics in the context of ecotoxicology, focusing mainly on the prospective research to be done in invertebrates. Although these represent around 95% of all animal species and in spite of the key structural and functional roles they play in ecosystems, proteomic research in invertebrates is still in an incipient stage. We will review applications of ecotoxicoproteomics by evaluating the technical methods employed, the organisms and the contexts studied, the advances achieved until now and lastly the limitations yet to overcome will be discussed.
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